Bot Detector
Download FREE Sample Issue or Article
Subscribe Today
A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

Clinical Management and Review of Sjogren's Syndrome

Author(s):  Dyke Shannon

Issue:  Sep/Oct 2000 - Compounding for Immune System Disorders
View All Articles in Issue

Abstract:  As many as 3% of Americans suffer from Sjogren’s syndrome, which affects populations worldwide and in all age groups. In this article, the author discusses the pathogenesis, symptoms and diagnosis of this disorder and treatment of ocular and oral symptoms (tear substitutes, antifungals, saliva substitutes, pilocarpine, anethole trithione, yohimbine and human interferon alpha). She also provides three formulas (Sodium Fluoride Gel [0.5% Fluoride] – 100 mL, Clotrimazole 10-mg Base A Troche – 24 Troches, and Saliva Substitute – 500 mL). She concludes that selection of treatment with the appropriate medications for patients with Sjogren’s syndrome depends on the severity of the symptoms, the clinical response to treatment and patient preference. For most patients, a regimen of oral pilocarpine (5 mg 4 times daily) plus the use of tear and saliva substitutes as needed is a beneficial combination. Less costly alternatives include stimulating saliva by chewing sugarless gum, sucking hard candy or using tear and saliva substitutes alone. Anethole trithione, yohimbine and natural human interferon alpha should be reserved for patients who cannot tolerate other treatments or who exhibit refractory disease.

Related Keywords: sjogren's, syndrome, autoimmune, saliva, salivary, mucous, lacrimal, secretions, xerophthalmia, xerostomia, dysphagia, tongue, lips, dryness, constipation, tear substitutes, artificial tears, antifungals, saliva substitutes, pilocarpine, anethole trithione, yohimbine, Human Interferon Alfa

Related Categories: DENTAL, EAR NOSE THROAT

Printer-Friendly Version

Download in electronic PDF format for $65

Related Articles from IJPC
Title (Click for Abstract / Details) Author Issue Page View/Buy
Clinical Management and Review of Sjogren's Syndrome Dyke Shannon Sep/Oct 2000 338 Buy
Xerostomia Kuntz Rachael, Allen Michelle, Osburn Jennifer May/Jun 2000 176-177 Buy
Low-dose Pilocarpine Spray to Treat Xerostomia Zur Eyal Mar/Apr 2020 104-108 Buy
Saliva Substitute for Dry Mouth/Throat Allen Loyd V Jr May/Jun 2000 215 Buy
Saliva Substitute Dyke Shannon Sep/Oct 2000 340 Buy
Artificial Tears for Dry Eyes Allen Loyd V Jr Sep/Oct 2000 376 Buy
Saliva Tests, Part 1: Clinical Use, Elements of Testing, and Guidelines for Posttreatment Interpretation Kells John, Dollbaum Charles M Jul/Aug 2009 280-288 Buy
Saliva Tests, Part 2: Salivary Hormones, Hormone Replacement Pharmacokinetics, and the Importance of Timely Testing Kells John, Dollbaum Charles M Sep/Oct 2009 392-399 Buy
Measuring Testosterone Biomarkers in Serum and Saliva: Are They Accurate? Tan Robert S Nov/Dec 2004 419-423 Buy
Surviving Cancer - How the Compounding Pharmacist Can Help Maddox Suzan Jul/Aug 2000 257-260 Buy
Particle Measuring Systems - USP <797> Environmental Monitoring Solutions