Bot Detector
IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC includes a print copy delivered by postal mail and on-line access to electronic PDF copies of your subscribed issues.

Basics of Pharmacogenomics for the Compounding Pharmacist

Author(s):  Kupiec Thomas C, Raj Vishnu

Issue:  Jul/Aug 2005 - Human Hormone Replacement Therapy
View All Articles in Issue

Page(s):  303-306

Basics of Pharmacogenomics for the Compounding Pharmacist Page 1
Basics of Pharmacogenomics for the Compounding Pharmacist Page 2
Basics of Pharmacogenomics for the Compounding Pharmacist Page 3
Basics of Pharmacogenomics for the Compounding Pharmacist Page 4

Download in electronic PDF format for $65

Abstract:  People respond in different ways to similar doses of a drug. A drug that works well in one person may have a very different effect in another individual. Pharmacogenomics is the study of interindividual genetic differences in drug disposition, and of the applications of these variations in selecting an optimal drug therapy and dosage for each individual. Most drug effects are determined by the interaction of several gene products such as drug targets, drug metabolizing enzymes, and transporters that influence the pharmacokinetics and pharmacodynamics of medications. Polymorphisms in genes encoding these targets may influence sensitivity to selected drugs by an indirect effect on drug response that is unrelated to drug metabolism or transport. The drug-metabolism type may be identified through phenotyping or genotyping. Phenotyping evaluates the level of activity of an enzyme that is purported to metabolize a group of drugs; from this enzyme activity, an individual is assigned a drug-metabolism profile, which

Related Keywords: Thomas C. Kupiec, PhD, Vishnu Raj, BDS, MSFS, Nicole Vu, PhD, PharmD, pharmacogenomics, pharmacogenetics, genetics, customized therapy, individualized therapy

Related Categories: TECHNOLOGY

Printer-Friendly Version



Related Articles from IJPC
Title/Author
(Click for Abstract / Details / Purchase)
Issue/​Page
View/Buy
Basics of Pharmacogenomics for the Compounding Pharmacist
Kupiec Thomas C
, Raj Vishnu
Jul/Aug 2005
Pg. 303-306

The Science Behind Hormone Replacement Therapy, Part 1
Wepfer Scott T
Nov/Dec 2001
Pg. 462-464

Novel Approaches to Topical Psoriasis Therapy
Koyama Gregory
, Liu Jenny, Scaffidi Alyse, Khazraee Maryam, Epstein Benjamin
Sep/Oct 2015
Pg. 357-365

Topical Metered-dosing Dispenser Performance Evaluation
Liu Qiang
, Kupiec Thomas C, Vu Nicole T
May/Jun 2016
Pg. 239-246

Quality-Control Analytical Methods: Applications and Sterility of Autologous Eye Drops
Reed-Kane Dana
, Carlson Rachel A, Kupiec Thomas C, Vu Nicole
Nov/Dec 2009
Pg. 540-543

Quality Control Analytical Methods: The Essentials of United States Pharmacopeia Chapter <51> Antimicrobial Effectiveness Testing and Its Application in Pharmaceutical Compounding
Vu Nicole
, Nguyen Devin, Kupiec Thomas C
Mar/Apr 2014
Pg. 123-130

Quality Control Analytical Methods: Microbial Limit Tests for Nonsterile Pharmaceuticals, Part 1
Vu Nicole
, Lou Jessica R, Kupiec Thomas
May/Jun 2014
Pg. 213-221

Quality Control: Microbial Limit Tests for Nonsterile Pharmaceuticals, Part 2
Vu Nicole
, Lou Jessica R, Kupiec Thomas C
Jul/Aug 2014
Pg. 305-310

Quality-Control Analytical Methods: Homogeneity of Dosing Forms
Kupiec Thomas C
, Vu Nicole, Branscum David
Jul/Aug 2008
Pg. 340-343

Biotechnology, Nanotechnology, and Pharmacogenomics and Pharmaceutical Compounding, Part 2
Allen Loyd V
Jul/Aug 2015
Pg. 280-287