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Abstract:  The purpose of this study was to assess the feasibility of extemporaneous compounding of slow-release oral dosage form of niacinamide and to evaluate its release kinetics. The model formulation (preparation) was developed in the form of powder-filled hard gelatin capsules. Two slow-release preparations with different ratios of hypromellose have been prepared and evaluated in comparison with an immediate-release preparation. The dissolution tests were performed as per United States Pharmacopoeia requirements: Type I Apparatus, over 7 hours. Both slow-release preparations, containing 40% and 60% v/v hypromellose, respectively, have showed slow release kinetics. The dissolution profiles were significantly different, with similarity factor f2<50. The dissolution data demonstrated Korsmeyer-Peppas kinetics with n values indicating anomalous transport. In conclusion, the results of this study suggest that slow-release niacinamide capsules can be successfully compounded using hypromellose as a sole release rate modifier, and that the release mechanism is comparable to hydrophilic polymer matrix-based systems.

Related Keywords: Branko Radojkovic, Bpharm, Jela Milic, PhD, Bojan Calija, Bpharm, niacinamide capsules, slow-release preparation, dissolution testing, hypromellose

Related Categories: CANCER AND AIDS, DERMATOLOGY, DIABETES, NUTRITION AND NUTRICEUTICALS, PEER-REVIEWED, DOSAGE FORMS/DRUG CARRIERS

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