Abstract

Effect of Penetration Enhancers on the Percutaneous Delivery of Pain Management Actives

Author(s): Trimble John, Light Bob

Issue: May/Jun 2016 - Volume 20, Number 3

Page(s): 250-256

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  • Effect of Penetration Enhancers on the Percutaneous Delivery of Pain Management Actives Page 1
  • Effect of Penetration Enhancers on the Percutaneous Delivery of Pain Management Actives Page 2
  • Effect of Penetration Enhancers on the Percutaneous Delivery of Pain Management Actives Page 3
  • Effect of Penetration Enhancers on the Percutaneous Delivery of Pain Management Actives Page 4
  • Effect of Penetration Enhancers on the Percutaneous Delivery of Pain Management Actives Page 5
  • Effect of Penetration Enhancers on the Percutaneous Delivery of Pain Management Actives Page 6
  • Effect of Penetration Enhancers on the Percutaneous Delivery of Pain Management Actives Page 7

Abstract

Transdermal compositions for pain management are comprised of nonsteroidal anti-inflammatory drugs, opioid drugs, and adjuvant drugs acting on: voltage-gated channels, gamma-aminobutyric acid receptors, acute musculoskeletal pain, and as an antidepressant. In this work, baclofen, bupivacaine, cyclobenzaprine, diclofenac, gabapentin, ibuprofen, ketamine, and pentoxifylline were loaded in transdermal compositions, prepared using a mixture of lipids (isopropyl palmitate and mineral oil) and one of two selected penetration enhancer mixtures: alkyl dimethicone, phenyl trimethicone, and polyoxyethylene sorbitan monostearate; and cetostearyl polyoxyethylene ether and ethylene oxide/propylene oxide copolymer. The influence of penetration enhancers on transdermal delivery was evaluated using Franz-type diffusion cells and Normal Human 3D Model of Epidermal Tissue. Results showed that drug delivery is affected by the penetration enhancer used in the transdermal composition.

Related Keywords

  • penetration enhancers
  • topical preparation
  • transdermal permeability
  • percutaneous drug delivery
  • skin penetration
  • pain
  • analgesia
  • analgesic
  • adjuvant pain control
  • voltage-gated channels
  • gamma-aminobutyric acid receptors
  • GABA receptors
  • acute musculoskeletal pain
  • muscle relaxants
  • antidepressants
  • baclofen
  • bupivacaine
  • cyclobenzaprine
  • diclofenac
  • gabapentin
  • ibuprofen
  • ketamine
  • pentoxifylline
  • nonsteroidal anti-inflammatory drug
  • NSAID
  • alkyl dimethicone
  • phenyl trimethicone
  • polyoxyethylene sorbitan monostearate
  • cetosteryl polyoxyethylene ether
  • ethylene oxide
  • propylene oxide copolymer
  • emulsifiers
  • lipids
  • engineered human skin

Related Categories

  • EXCIPIENTS
  • PAIN MANAGEMENT
  • PEER-REVIEWED
  • DOSAGE FORMS/DRUG CARRIERS

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