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Topical Cholesterol/Simvastatin Gel for the Treatment of CHILD Syndrome in an Adolescent

Author(s):  Cho Sung Kyung, Ashworth Lisa Diggs, Goldman Shauna

Issue:  Sep/Oct 2020 - Volume 24, Number 5
View All Articles in Issue

Page(s):  367-369

Topical Cholesterol/Simvastatin Gel for the Treatment of CHILD Syndrome in an Adolescent Page 1
Topical Cholesterol/Simvastatin Gel for the Treatment of CHILD Syndrome in an Adolescent Page 2
Topical Cholesterol/Simvastatin Gel for the Treatment of CHILD Syndrome in an Adolescent Page 3

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Abstract:  Congenital ichthyoses are a heterogeneous group of genetic skin disorders characterized by defects in the critical barrier function of the skin. These life-long conditions present a significant therapeutic challenge in dermatology. One important example is Congenital Hemidysplasia with Ichthyosiform erythroderma and Limb Defects, or CHILD syndrome. This is a rare congenital ichthyosis caused by mutations in cholesterol biosynthesis. With limited success, the cutaneous features of this condition have historically been managed symptomatically with emollients, topical keratolytics, and topical steroids. However, over the last decade, topical therapy directed at the pathogenesis of this condition has emerged as an effective treatment. Herein, we report a case of successful treatment of the cutaneous features of CHILD syndrome with compounded simvastatin and cholesterol gel and highlight the role of the compounding pharmacist in the care of patients with congenital ichthyosis.

Related Keywords: Sung Kyung Cho, BA, Lisa Diggs Ashworth, BS Pharm, RPh, FACA, Shauna Goldman, MD, congenital hemidysplasia with ichthyosiform erythroderma and limb defects, CHILD syndrome, congenital ichthyosis, cholesterol biosynthesis disorder, topical preparations, case report, adolescent, skin rash, cholesterol, simvastatin, skin disorders, formulation

Related Categories: DERMATOLOGY, FORMULATIONS, CASE REPORTS, DOSAGE FORMS/DRUG CARRIERS

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