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Stability of Cefepime Hydrochloride Dextrose in 5% Dextrose Injection and 0.9% Sodium Chloride Injection

Author(s):  Gupta Vishnu D, Maswoswe J, Bailey RE

Issue:  Nov/Dec 1997 - Diverse Ambulatory Patients
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Abstract:  The stability of cefepime hydrochloride in 5% dextrose injection and 0.9% sodium chloride injection was studied using a stability- indicating assay method developed in our laboratory. This method is precise and accurate, with a percent relative standard deviation of 0.7% based on five readings. The admixtures were stable for two days at 25°C and 23 days at 5°C. The pH values of the admixtures did not change throughout this study, and the colors had changed from a very light yellow to a light yellow. The manufacturer recommends an expiry date of 24 hours at 20 to 25°C and seven days at 2 to 8°C.


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