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Treating Inner Ear Disorders with Intratympanic Drug Administration

Author(s):  McElhiney Linda F

Issue:  Jul/Aug 2011 - Volume 15, Number 4
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Abstract:  Inner ear diseases are often treated in outpatient clinic settings that do not have United States Pharmacopeia Chapter <797>-compliant facilities to prepare the medications used for intratympanic administration. Compounding pharmacists can provide a valuable service to otolaryngologists by preparing these compounds in a sterile environment and hopefully reduce the chance of infection for these patients. This article focuses on the use and compounding of intratympanic dexamethasone to treat sudden sensorineural hearing loss and the use of intratympanic buffered gentamicin to treat the incapacitating vertigo in Ménière’s disease.

Related Keywords: Linda F. McElhiney, PharmD, RPh, FIACP, FASHP, inner ear disorders, hearing disorders, presbycusis, age-related hearing loss, sudden sensorineural hearing loss, ototoxic drugs, Meniere disease, benign positional vertigo, labyrinthitis, steroids, anti-inflammatory agents, intratympanic administration, dexamethasone, buffered gentamicin, formulations, drug delivery, hydrogels, tympanic membrane, ear drum, ear canal, myringotomy, ventilation tubes

Related Categories: EAR NOSE THROAT, FORMULATIONS, ALLERGY/IMMUNOLOGY/INFLAMMATION, DOSAGE FORMS/DRUG CARRIERS

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