Stability of Bethanechol Chloride Oral Liquid Dosage Forms

Author(s):  Gupta Vishnu D, Maswoswe J

Issue:  Jul/Aug 1997 - Compounding for Animals
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Abstract:  The chemical stability of bethanechol aqueous solutions prepared using either tablets, injection or powder was studied. For an aqueous solution prepared using tablets, the initial result was low (86.5%) and the pH value was 7.1. With storage at 25°C, the result increased to almost 100% in 12 days and the pH value decreased to about 3.4. For the solution prepared from the injection, the initial result was 100%. After 40 days’ storage at 25°C, the pH value decreased from 7.0 to 6.0 and the result was still almost 100% of the label claim. The aqueous solutions prepared from powder in phosphate buffers (pH values between 3.0 and 6.8) retained almost 100% of the potency at all pH values.

Related Categories: GERIATRICS, PEDIATRICS, PEER-REVIEWED, STABILITIES, COMPATIBILITIES

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