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Intravenous Admixture Preparation Considerations, Part 6: pH Considerations -- Applications

Author(s):  Allen Loyd V Jr

Issue:  Sep/Oct 2020 - Volume 24, Number 5
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Abstract:  In the formulation of parenteral dosage forms, pH is a critical factor and can be a complicated factor in compounding intravenous admixtures since the additives and the vehicle may have different pH values. This is especially important, as a significant number of parenteral medications require compounding involving dissolution of lyophilized powders; dilution of drug doses for infusion; mixing of dextrose, amino acids, vitamins, and electrolytes for parenteral nutrition; etc. Compounding intravenous admixtures is common practice, but each admixture may present a different set of problems to consider, especially as it relates to pH.

Related Keywords: Loyd V. Allen, Jr., PhD, RPh, intravenous drug admixtures, parenteral preparations, acid-base drug environment, solubility, stability, parenteral vehicles, pH, USP injections, small-volume parenterals, large-volume parenterals


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