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Sterile Basics: Compounding Sterile Preparations with Cyclodextrins

Author(s):  Allen Loyd V Jr

Issue:  Jan/Feb 2022 - Volume 26, Number 1
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Abstract:  Complexation is a powerful therapeutic as well as a pharmaceutical tool. Many categories of medications contain complexes which aid in the solubilization and stabilization of the drugs they contain. Some also contain complexes which are useful for treating poisonings, increasing pharmacological activity, improving drug distribution, and enhancing bioavailability. In this article, we limit our discussion to organic molecular complexes.

Related Keywords: Loyd V. Allen Jr., PhD, RPh, complexation, solubilization, stabilization, drug stability, drug solubility, compounded sterile preparations, cyclodextrin, cyclic oligosaccharides, organic molecular complexes, inclusion compounds, occlusion compounds, no-bond complexes, monomolecular inclusion compounds, complexing agents, in vivo drug delivery

Related Categories: EXCIPIENTS, FORMULATIONS, STABILITIES, COMPATIBILITIES, STERILE PREPARATIONS

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