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Stability of Oral Liquid Dosage Forms of Ethacrynic Acid

Author(s):  Gupta Vishnu D, Ling Jie

Issue:  May/Jun 2001 - The Business of Compounding
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Abstract:  The stability of ethacrynic acid (2.5 mg/mL) in oral liquid dosage forms was investigated. Tablets in 0.05 M phosphate buffer (available commercially) in water were used to prepare the dosage forms. The effects of mannitol and sugar on the stability of ethacrynic acid were negligible. There was no change in the physical appearance of the oral liquid dosage forms or pH values during the study. There was, however, a new peak in the chromatogram from the product(s) of decomposition. An oral liquid dosage form of ethacrynic acid containing 0.05 M phosphate buffer and 10% mannitol was stable for 24 days when stored at 5°C and for only 3 days when stored at 25°C.

Related Keywords: Ethacrynic acid, dosage forms of, oral liquid, Ethacrynic acid, stability of, oral liquid dosage forms


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