**Calculations**

**Author(s):** Prince Shelly J

**Issue:** Sep/Oct 2000 - Compounding for Immune System Disorders

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**Abstract: **The author shows the reader how to perform the calculations to solve four problems. The first involves the administration of intravenous immune globulin for treating immunodeficiency syndrome. The reader is shown how to calculate the quantity of immune globulin that should be administered to a patient weighing a certain weight to deliver a dose of 300 mg/kg, how to calculate the quantity of solution that should be infused to deliver a dose of 300 mg/kg and how to calculate how long it would take to infuse the calculated volume. The second involves granulocyte-macrophage colony stimulating factor and shows how to calculate the dose for a patient with a specified body surface area, the final concentration of the solution, the quantity of albumin that needs to be added to the infusion when using 50 mL of saline for the dilution, the quantity of the solution needed to prepare the infusion and the quantity of sodium the patient would receive from this infusion. The third involves a formula for cyclosporine ophthalmic solution and shows the reader how to calculate the quantity of the solution that would be required to prepare 30 mL of the solution, the quantity of corn oil or olive oil that would need to be added to prepare the final solution and the quantity of corn oil or olive oil that would need to be added to dilute the solution to a final concentration of 1.5% cyclosporine. The fourth involves a formulation containing zinc oxide, calamine and petrolatum. The reader is shown how to calculate the quantity of a 20% w/w zinc oxide ointment that should be added to change the strength to 12.5% w/w of zinc oxide.

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