Logo - International Journal of Pharmaceutical Compounding

Stability of an Extemporaneously Formulated Levothyroxine Sodium Syrup Compounded from Commercial Tablets

Author(s):  Alexander Kenneth S, Kothapalli Madhu R, Dollimor David

Issue:  Jan/Feb 1997 - Hospice Care
View All Articles in Issue

Note:  Electronic version includes errata or revisions.

Abstract:  The stability of a 40-µg/mL extemporaneously formulated syrup from commercially available levothyroxine sodium tablets, using sorbitol 70% as the diluting vehicle, was studied. The concentration of levothyroxine sodium in the formulation was 40 µg/mL. The protocol included accelerated stability testing at temperatures of 40°, 50°, 60° and 70°C and a high-performance liquid chromatography assay procedure using testosterone propionate as the internal standard. The data were analyzed using an Arrhenius plot to determine the shelf-life of the formulation. The shelf-life was found to be approximately 15 days at 25°C and 47 days at 5°C.

Related Keywords: Synthroid

Related Categories: GERIATRICS, PEDIATRICS, PEER-REVIEWED, STABILITIES, COMPATIBILITIES

Purchase this article for download in electronic PDF format from IJPC at for $35 at:
http://www.ijpc.com/Products/ProductAddToCart.cfm?PID=174

Search the entire IJPC archive by keyword, topic, or issue at:
http://ijpc.com/Products