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Compatibility of Caspofungin Acetate Injection with Other Drugs During Simulated Y-Site Coadministration

Author(s):  Chan Pak, Heatherly Kathy, Kupiec Thomas C, Trissel Lawrence A

Issue:  May/Jun 2008 - Pain Management
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Abstract:  The physical compatibility of caspofungin acetate injection with selected other drugs during simulated Y-site coadministration was evaluated by visual observation and turbidity measurement. Five-milliliter samples of caspofungin acetate 0.7 mg/mL in 0.9% sodium chloride injection were combined with 5 mL of 67 other drugs including antineoplastics, analgesics, anti-infectives, and supportive care drugs, undiluted or diluted in 0.9% sodium chloride injection or 5% dextrose injection, and with a parenteral nutrition admixture. Visual examinations were performed with the unaided eye in normal laboratory fluorescent light and with a Tyndall beam (high-intensity monodirectional light beam) to enhance visualization of small particles and low-level turbidity. The turbidity of each sample was measured as well. The sample mixtures were evaluated immediately and at 1 and 4 hours after preparation. Nineteen of the drugs tested and the parenteral nutrition admixture were incompatible with caspofungin acetate 0.7 mg/mL dur

Related Keywords: Pak Chan, Kathy Heatherly, MS, Thomas C. Kupiec, PhD, Lawrence A. Trissel, BS, RPh, FASHP, caspofungin acetate, drug admixtures, infusion, Y-site administration, parenteral administration, compatibility, stability, total parenteral nutrition


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