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Coenzyme Q10 Supplementation in the Treatment of Heart Disease

Author(s):  Bramwell Bethany L

Issue:  Mar/Apr 2010 - Compounding for Men
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Abstract:  Significant deficiencies in coenzyme Q10 have been documented in a wide variety of diseases in both animal and human studies. Known predominately for its functions as an antioxidant and membrane stabilizer, coenzyme Q10 supplementation also has been demonstrated to effectively lower blood pressure, decrease total cholesterol and low-density lipoprotein cholesterol, increase levels of high-density lipoprotein cholesterol, and decrease symptoms of dyspnea, peripheral edema, enlarged liver, and insomnia. The majority of clinical work with coenzyme Q10 in the past two decades has focused on its role in heart disease. While usually found in high concentrations in heart muscle cells, both serum and tissue levels of coenzyme Q10 are often lower in people with congestive heart failure. The severity of coenzyme Q10 deficiency is directly related to the severity of heart failure. Correcting deficits in coenzyme Q10 in heart failure patients can mitigate or reverse myocardial dysfunction and necrosis. The addition of co

Related Keywords: Bethany L. Bramwell, BS Pharm, RPh, heart disease, cardiovascular disease, coenzyme Q10, nutritional supplement, dietary supplementation, high blood pressure, hypertension, cholesterol, low-density lipoprotein, LDL, antioxidant, congestive heart failure, oxidative stress, statins, myocardial infarction, transdermal application, formulation


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