Compounding Rifampin Suspensions with Improved Injectability for Nasogastric Enteral Feeding Tube Administration

Author(s):  de Villiers Melgardt M, Vogel Laura, Bogenschutz Monica C, Fingerhut Bonnie J, D'Silva Joseph B, Moore Anne

Issue:  May/Jun 2010 - Pain Management
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Abstract:  Often medications that have to be administered to patients via a nasogastric enteral feeding tubes are only available as tablets and capsules with no suitable commercial liquids alternatives. In such situations, pharmacists and nurses have to compound the tablets and capsule contents into liquid suspension formulations for dosing. The risk of occlusion of the enteral tubes during administration is reduced by employing liquid suspensions that are composed of small and uniform particles, not subject to rapid rates of settling, resistant to caking, and easily and uniformly resuspended upon agitation. Present techniques often employ a manual process, such as a mortar and pestle, to accomplish the particle size reduction and subsequent incorporation into a suitable liquid diluent. A new compounding device has been invented that employs an automated wet-milling process in a single-use disposable plastic container to compound the suspensions. The two processes were compared using Rifampin capsules and various liquid

Related Keywords: Anne Moore, Ingenieur ENSCP, DEA, nasogastric enteral feeding tube, liquid suspension preparations, rifampin, antibiotic, antimicrobial agent, antitubercular agent, tuberculosis, nasogastric tube injectability test, particle size, tube blockage

Related Categories: FORMULATIONS, PEER-REVIEWED, STABILITIES, COMPATIBILITIES, QUALITY CONTROL, DOSAGE FORMS/DRUG CARRIERS, INFECTIOUS DISEASE

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