Basics of Compounding: Basics of Compounding with Esters

Author(s):  Allen Loyd V Jr

Issue:  Sep/Oct 2010 - Supporting Quality Pharmaceutical Compounding World Wide
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Abstract:  Pharmacists involved in compounding must consider a number of factors when determining the actual quantity of an active ingredient to use for a compounded prescription. Is the drug being dosed as its base form or as a salt, ester, etc.? Since the bulk substance, or active pharmaceutical ingredient, is not 100% active drug in all cases, then it is important to know whether or not the dose of the drug is based upon the drug ester or drug base form. This article discusses the basics of compounding with those drugs that are esters by the addition of a moiety that will form an ester for certain purposes.

Related Keywords: Loyd V. Allen, Jr., PhD, RPh, esters, solubility, prodrugs

Related Categories: SUPPORT, QUALITY CONTROL, UNITED STATES PHARMACOPEIA CONVENTIONS

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