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Formulation and Stability of Solutions

Author(s):  Akers Michael J

Issue:  Jan/Feb 2016 - Volume 20, Number 1
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Abstract:  Ready-to-use solutions are the most preferable and most common dosage forms for injectable and topical ophthalmic products. Drugs formulated as solution almost always have chemical and physical stability challenges as well as solubility limitations and the need to prevent inadvertent microbial contamination issues. This article, which takes us through a discussion of optimizing the physical stability of solutions, represents the first of a series of articles discussing how these challenges and issues are addressed.

Related Keywords: Michael J. Akers, PhD, ready-to-use solutions, compounded sterile preparations, sterile dosage forms, sterile drug solutions, biopharmaceuticals, instability, aggregation, precipitation, hydrolytic stability, drug degradation mechanisms, stabilizing additives, storage temperature, hydrolysis, potency, therapeutic proteins, large molecules, optimal solution pH, solubility, quality control, amino acid sequence, buffers, dissociation constants, oxidation, oxidative stability, antioxidants, chelating agents, inert gases, physical stability, denaturation

Related Categories: PACKAGING, PARENTERALS, STABILITIES, COMPATIBILITIES, STERILE PREPARATIONS, DOSAGE FORMS/DRUG CARRIERS, STORAGE

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