Basics of Compounding with Dilutions and Concentrates

Author(s):  Allen Loyd V Jr

Issue:  Jan/Feb 2017 - Volume 21, Number 1
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Abstract:  Pharmacists use various sources for obtaining the active pharmaceutical ingredient for compounding medications. In many cases, it is the pure drug (United States Pharmacopeia, National Formulary, or similar grade); in some cases, it can be a commercial dosage form; and, in some cases, it may be a dilution or concentrate. If the drug is not present at full strength, then adjustments may be necessary to obtain the required quantity of drug. Also, in many cases, it is necessary to use a dilution or a concentrate of a drug due to safety and quality reasons. Presented within this article are new sources of active pharmaceutical ingredients that are now available to aid pharmacists in meeting future United States Pharmacopeia <800> standards. It is critical that the pharmacist be aware of the strength of the drug and any other excipients that may be available.

Related Keywords: trituration, dilution, concentrates, stock preparations, liothyronine sodium, T3, levothyroxine sodium, T4, thyroid replacement, thyroid disorders, solid dilutions, stablity, liquid dilutions, aqueous concentrates, oil concentrates, sex hormones, sex steroids, estrogens, estrone, E1, estradiol, E2, estriol, E3, progesterone, P4, androgen, testosterone, menopause, hormone replacement therapy, HRT, hormone ratios, calculation aid

Related Categories: EXCIPIENTS, FORMULATIONS, HRT, SUPPORT, QUALITY CONTROL

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