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Effect of Penetration Enhancers on the Percuaneous Delivery of Hormone Replacement Actives

Author(s):  Trimble John O, Light Bob

Issue:  Nov/Dec 2017 - Volume 21, Number 6
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Abstract:  Transdermal compositions for hormone replacement are comprised of exogenous hormones that are biochemically similar to those produced endogenously by the ovaries or elsewhere in the body. In this work, estradiol, estriol, and testosterone were loaded in transdermal vehicles, prepared using one of three selected penetration enhancer mixtures: Vehicle 1 (olive oil and oleic acid), Vehicle 2 (isopropyl palmitate and lecithin), and Vehicle 3 (isopropyl myristate and lecithin). The influence of penetration enhancers on transdermal delivery was evaluated using Franz-type diffusion cells and Normal Human 3D Model of Epidermal Tissue. Results showed that drug delivery is affected by the penetration enhancer used in the transdermal composition.

Related Keywords: Bob Light, BS Pharm, hormone replacement therapy, HRT, adverse effects, estradiol, estiol, biest, testosterone, estrogens, transdermal delivery, percutaneous delivery, skin penetration enhancer, skin permeation, olive oil, oleic acid, isopropyl palmitate, lecithin, isopropyl myristate, Franz-type diffusion cell, Normal Human 3D Model of Epidermal Tissue, human dermal models, hydrophile-lipophile balance, HLB, drug solubilizing, drug solubility


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