Effect of Penetration Enhancers on the Percuaneous Delivery of Hormone Replacement Actives

Trimble, John O; Light, Bob

A subscription to IJPC provides on-line access to full-text, full-color, printable PDF copies of all issues and individual articles published by the Journal since 1997.

LEARN MORE

Effect of Penetration Enhancers on the Percuaneous Delivery of Hormone Replacement Actives

Author(s): Trimble John O, Light Bob

Issue: Nov/Dec 2017 - Volume 21, Number 6
View All Articles in Issue

Page(s): 530-535

Effect of Penetration Enhancers on the Percuaneous Delivery of Hormone Replacement Actives Page 1

Effect of Penetration Enhancers on the Percuaneous Delivery of Hormone Replacement Actives Page 2

Effect of Penetration Enhancers on the Percuaneous Delivery of Hormone Replacement Actives Page 3

Effect of Penetration Enhancers on the Percuaneous Delivery of Hormone Replacement Actives Page 4

Effect of Penetration Enhancers on the Percuaneous Delivery of Hormone Replacement Actives Page 5

Effect of Penetration Enhancers on the Percuaneous Delivery of Hormone Replacement Actives Page 6

Download in electronic PDF format for $75

Abstract: Transdermal compositions for hormone replacement are comprised of exogenous hormones that are biochemically similar to those produced endogenously by the ovaries or elsewhere in the body. In this work, estradiol, estriol, and testosterone were loaded in transdermal vehicles, prepared using one of three selected penetration enhancer mixtures: Vehicle 1 (olive oil and oleic acid), Vehicle 2 (isopropyl palmitate and lecithin), and Vehicle 3 (isopropyl myristate and lecithin). The influence of penetration enhancers on transdermal delivery was evaluated using Franz-type diffusion cells and Normal Human 3D Model of Epidermal Tissue. Results showed that drug delivery is affected by the penetration enhancer used in the transdermal composition.

Related Keywords: hormone replacement therapy, HRT, adverse effects, estradiol, estiol, biest, testosterone, estrogens, transdermal delivery, percutaneous delivery, skin penetration enhancer, skin permeation, olive oil, oleic acid, isopropyl palmitate, lecithin, isopropyl myristate, Franz-type diffusion cell, Normal Human 3D Model of Epidermal Tissue, human dermal models, hydrophile-lipophile balance, HLB, drug solubilizing, drug solubility

Related Categories: EXCIPIENTS, HRT, PEER-REVIEWED

Printer-Friendly Version

Title/Author (Click for Abstract / Details / Purchase)	Issue/Page View/Buy
Related Articles from IJPC
Effect of Penetration Enhancers on the Percuaneous Delivery of Hormone Replacement Actives Trimble John O, Light Bob	Nov/Dec 2017 Pg. 530-535
Effect of Penetration Enhancers on the Percutaneous Delivery of Pain Management Actives Trimble John, Light Bob	May/Jun 2016 Pg. 250-256
Using Serum Hormone Analysis to Develop Hormone Replacement Therapy Regimens - Part 2 Ford Gina, Garcia Lea	Jan/Feb 2001 Pg. 52-54
Menopausal Symptom Relief and Side Effects Experienced by Women Using Compounded Bioidentical Hormone Replacement Therapy and Synthetic Conjugated Equine Estrogen and/or Progestin Hormone Replacement Therapy, Part 2 Deleruyelle Laura J	Nov/Dec 2016 Pg. 447-454
Menopausal Symptom Relief and Side Effects Experienced by Women Using Bioidentical Hormone Replacement Therapy and Synthetic Conjugated Equine Estrogen and/or Progestin Hormone Replacement Therapy, Part 1 Deleruyelle Laura J	Sep/Oct 2016 Pg. 359-364
Transdermals: The Skin as Part of a Drug Delivery System Allen Loyd V Jr	Jul/Aug 2011 Pg. 308-315
Featured Excipient: Flavor Enhancing Agents Allen Loyd V Jr	Jan/Feb 2003 Pg. 48-50
Menopausal Symptom Relief and Side Effects Experienced by Women Using Compounded Bioidentical Hormone Replacement Therapy and Synthetic Conjugated Equine Estrogen and/or Progestin Hormone Replacement Therapy, Part 3 Deleruyelle Laura J	Jan/Feb 2017 Pg. 6-16
The Effects of Compounded Bioidentical Transdermal Hormone Therapy on Hemostatic, Inflammatory, and Immune Factors; Cardiovascular Biomarkers; Quality of Life Measures; and Health Outcomes in Perimenopausal and Postmenopausal Women Stephenson Kenna, Neuenschwander Pierre F, Kurdowska Anna K	Jan/Feb 2013 Pg. 74-85 View Sample
A Perspective on HRT for Women: Picking Up the Pieces After the Women's Health Initiative Trial - Part 1 Gillson George R, Zava David T	Jul/Aug 2003 Pg. 250-256
Efficacy and Clinical Value of Commonly Compounded Hormone Replacement Therapy: A Literature Review Beshay Sarah M, Rivera Gerard, Balthasar Jan, Florea Naomi	Jan/Feb 2015 Pg. 6-12
Veterinary Transdermal Medications: A to Z Davidson Gigi S	Mar/Apr 2003 Pg. 106-113
Bilateral Areolar Hyperpigmentation Following Transdermal Administration of Compounded Hormone Replacement Therapy Griffee Chris, Delano Amy	Mar/Apr 2012 Pg. 110-114
Saliva Tests, Part 2: Salivary Hormones, Hormone Replacement Pharmacokinetics, and the Importance of Timely Testing Kells John, Dollbaum Charles M	Sep/Oct 2009 Pg. 392-399
Bioidentical Hormone Replacement Therapy, Part 3, A Review of Wepfer Scott T	Mar/Apr 2002 Pg. 142-146
Establishing a Rationale for Compounding Hormone Replacement Therapy Biundo Bruce	May/Jun 2018 Pg. 190-195
Establishing a Rationale for Compounding Hormone Replacement Therapy Biundo Bruce	Jan/Feb 2024 Pg. 22-27
Chemical Penetration Enhancers Newton Stephen J	Sep/Oct 2013 Pg. 370-374
Transdermal Delivery of Nisoldipine: Refinement of Vehicles El Maghraby Gamal M, Ahmed Amal A, Osman Mohamed A	Mar/Apr 2015 Pg. 152-160
Bioidentical Hormone Replacement Therapy, Part 2, A Review of Wepfer Scott T	Jan/Feb 2002 Pg. 50-54
Return to Top