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Intravenous Admixture Preparation Considerations, Part 3: Methods and Techniques to Decrease Incompatibilities

Author(s):  Allen Loyd V Jr

Issue:  Mar/Apr 2020 - Volume 24, Number 2
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Abstract:  The study of intravenous admixture compatibility is an excellent application of “clinical pharmaceutics.” Clinical pharmaceutics involves the study and application of pharmaceutics and pharmaceutic (physical pharmacy/ chemistry) principles to clinical compounding situations to aid in the evaluation of each intravenous admixture. This series includes compatibility and stability considerations in intravenous admixture compounding. Part 2 of this series of articles discussed many factors that should be considered that may give rise to compatibility concerns, as well as drug sorption issues. In this issue (Part 3), there is a discussion on the methods and techniques that can be used to decrease the occurrence and incidence of incompatibilities, along with some alternate techniques to consider when some approaches do not seem feasible.

Related Keywords: Loyd V. Allen, Jr., PhD, RPh, intravenous drug admixtures, compatibility, incompatibilities, reconstitution timing, dilution factor, mixing, sorption, Y sites, concentration, complexation, light sensitivity, freezing, thawing, silicone oil, overfill

Related Categories: PARENTERALS, STABILITIES, COMPATIBILITIES, STERILE PREPARATIONS

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