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Basics of Compounding: Excipients Used in Nonsterile Compounding, Part 10: Rectal Suppository Bases

Author(s):  Allen Loyd V Jr

Issue:  Jul/Aug 2021 - Volume 25, Number 4
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Abstract:  The selection of a rectal suppository base can be critical for proper compounding, storage, administration, and release of the drug for the patient. In this article, a number of different characteristics are discussed, as well as potential compatibility and stability issues. Also, a number of example bases are presented and discussed.

Related Keywords: Loyd V. Allen Jr., PhD, RPh, rectal suppositories, rectal suppository bases, drug availability, drug release, drug solubility, excipients, melting point, water-soluble bases, fatty bases, solutions, suspensions, cocoa butter, polymorphism, incompatibilities, hydrogenated vegetable oil bases, compatibility, polyethylene glycols, glycerin water bases, gelatin bases, poloxamers

Related Categories: EXCIPIENTS, STABILITIES, COMPATIBILITIES, DOSAGE FORMS/DRUG CARRIERS

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