Basics of Sterile Compounding: Sterile Basics of Compounding Intravenous Admixtures, Part 4: Physicochemical Considerations

Author(s):  Allen Loyd V Jr

Issue:  Sep/Oct 2023 - Volume 27, Number 5
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Abstract:  Intravenous admixture compounding is common practice in most hospitals throughout the world, regardless of the country. Compounding intravenous medications involves risk, as there is a high potential for error due to their complexity in compounding as well as the additional issues that working in an aseptic compounding environment poses for the compounder. This article in a series of intravenous admixture compounding discusses considerations involved when using commercial products in compounding, as well as a discussion on the issues of freezing, solubility, sorption, leaching, incompatibilities, and quality control, with an emphasis on physicochemical considerations.

Related Keywords: intravenous admixtures, compounded sterile preparations, hospital pharmacy, parenteral administration, drug errors, drug safety, excipients, chemical stability, physical stability, sorption, leaching, incompatibilities, complexation, concentration, light sensitivity, pH effects, solubility, contamination, particulate matter, adverse effects

Related Categories: EXCIPIENTS, FORMULATIONS, PARENTERALS, STABILITIES, COMPATIBILITIES, STERILE PREPARATIONS, HOSPITAL PHARMACY

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