Stability of Cefepime Hydrochloride After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use

Author(s):  Gupta Vishnu D, Ling Jie

Issue:  Mar/Apr 2001 - Compounding for Animals
View All Articles in Issue

Abstract:  A stability-indicating high-performance liquid chromatography (HPLC) assay method was used to study the stability of cefepime hydrochloride (20 mg/mL) in 0.9% sodium chloride injection at 25°C and 5°C in polypropylene syringes. The concentrations of the drug were directly related to peak heights, and the percent relative standard deviation based on five injections was 1.1. L-arginine that is added to the powder for injection did not interfere with the assay. Two products of decomposition separated from the intact drug. At 25°C, the loss in potency was less than 6% after 2 days of storage, and at 5°C the loss in potency was less than 3% when stored for 21 days. The pH value of the injection did not change when stored at 25°C for 2 days and at 5°C for 21 days. The drug was not adsorbed onto the syringes, and the physical appearance of the injection did not change during 2 days of storage at 25°C and 21 days at 5°C.

Related Keywords: cefepime, cefepime injection, cefepime stability, cefepime storage

Related Categories: PEER-REVIEWED, STABILITIES, COMPATIBILITIES

Purchase this article for download in electronic PDF format from IJPC at for $35 at:
http://www.ijpc.com/Products/ProductAddToCart.cfm?PID=747

Search the entire IJPC archive by keyword, topic, or issue at:
http://ijpc.com/Products