Stability of Cefepime Hydrochloride After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use
Download in electronic PDF format for $65
Abstract: A stability-indicating high-performance
liquid chromatography
(HPLC) assay method was used to study
the stability of cefepime hydrochloride
(20 mg/mL) in 0.9% sodium chloride injection
at 25°C and 5°C in polypropylene
syringes. The concentrations of
the drug were directly related to peak
heights, and the percent relative standard
deviation based on five injections
was 1.1. L-arginine that is added to the
powder for injection did not interfere
with the assay. Two products of decomposition
separated from the intact
drug. At 25°C, the loss in potency was
less than 6% after 2 days of storage,
and at 5°C the loss in potency was less
than 3% when stored for 21 days. The
pH value of the injection did not change
when stored at 25°C for 2 days and at 5°C
for 21 days. The drug was not adsorbed
onto the syringes, and the physical appearance
of the injection did not change
during 2 days of storage at 25°C and 21
days at 5°C.
Related Keywords:
cefepime, cefepime injection, cefepime stability, cefepime storage
Related Articles from IJPC |
Title/Author
(Click for Abstract / Details / Purchase) |
Issue/Page
View/Buy |
Stability of Cefepime Hydrochloride After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use
Gupta Vishnu D, Ling Jie
|
Mar/Apr 2001
Pg. 151-152
|
Effect of Freezing, Long-Term Storage, and Microwave Thawing on the Stability of Cefepime in 5% Dextrose Infusion Polyvinyl Chloride Bags
Schlesser Vincent, Hecq Jean-Daniel, Vanbeckbergen Danielle, Jamart Jacques, Galanti Laurence M
|
Sep/Oct 2002
Pg. 391-394
|
Cefepime Hydrochloride 100-mg/mL Injection
Allen Loyd V Jr
|
Nov/Dec 2015
Pg. 505
|
Cefepime 1% Ophthalmic Solution
Allen Loyd V Jr
|
Nov/Dec 2011
Pg. 500
|
Stability of Cefepime Hydrochloride Dextrose in 5% Dextrose Injection and 0.9% Sodium Chloride Injection
Gupta Vishnu D, Maswoswe J, Bailey RE
|
Nov/Dec 1997
Pg. 435-436
|
Stability of Aminocaproic Acid Injection Admixtures in 5% Dextrose Injection and 0.9% Sodium Chloride Injection
Zhang Yan-ping, Trissel Lawrence A
|
Mar/Apr 1997
Pg. 132-134
|
Stability of Lidocaine Hydrochloride Injection at Ambient Temperature and 4°C in Polypropylene Syringes
Storms Meredith L, Stewart James T, Warren Flynn W
|
Sep/Oct 2002
Pg. 388-390
|
pH Stability of Injectable Fentanyl, Bupivacaine, or Clonidine Solution or a Ternary Mixture in 0.9% Sodium Chloride in Two Types of Polypropylene Syringes
Jappinen Annaliisa L, Kokki H, Rasi A S, Naaranlahti Toivo J
|
Nov/Dec 2002
Pg. 471-474
|
Effect of Freezing, Long-Term Storage and Microwave Thawing on the Stability of Tramadol in 5% Dextrose Infusion in Polyvinyl Chloride Bags
Lebrun John, Hecq Jean-Daniel, Vanbeckbergen Danielle, Jamart Jacques, Galanti Laurence M
|
Mar/Apr 2004
Pg. 156-159
|
Stability of Ethacrynate Sodium After Reconstitution in 0.9% Sodium Chloride Injection and Storage in Polypropylene Syringes for Pediatric Use
Gupta Vishnu D, Ling Jie
|
Jan/Feb 2001
Pg. 73-75
|