Compatibility of Micafungin Injection with Other Drugs During Simulated Y-Site Co-administration

Author(s):  Trusley Craig, Kupiec Thomas C, Trissel Lawrence A

Issue:  May/Jun 2006 - Hormone Replacement Therapy
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Abstract:  The objective of this study was to evaluate the physical compatibility of micafungin injection with selected other drugs during simulated Y-site co-administration. Physical stability was assessed by both visual observation and turbidity measurement. Micafungin in 0.9% sodium chloride injection was combined with each of 48 other drugs, including antineoplastics, analgesics, anti-infectives, and supportive care drugs undiluted or diluted in 0.9% sodium chloride injection, and with a parenteral nutrition admixture. Visual examinations were performed with the unaided eye in fluorescent light and by using a Tyndall beam, and the turbidity of each sample was measured. The samples were evaluated immediately after mixing and again 1 and 4 hours after preparation. Twenty nine of the drugs tested were found to be compatible for at least 4 hours. The measured turbidity of the micafungin control solutions and the compatible test samples remained essentially unchanged throughout the study. The other 19 drugs exhibited fra

Related Keywords: micafungin, antifungal agent, fungal infection, fungus, Candida spp., esophageal candidiasis, compatibility, drug admixtures

Related Categories: PEER-REVIEWED, STABILITIES, COMPATIBILITIES, INFECTIOUS DISEASE

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