Compatibility of Micafungin Injection with Other Drugs During Simulated Y-Site Co-administration

Trusley, Craig; Kupiec, Thomas C; Trissel, Lawrence A

Abstract

Compatibility of Micafungin Injection with Other Drugs During Simulated Y-Site Co-administration

Author(s): Trusley Craig, Kupiec Thomas C, Trissel Lawrence A

Issue: May/Jun 2006 - Hormone Replacement Therapy

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Page(s): 230-233

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Abstract

The objective of this study was to evaluate the physical compatibility of micafungin injection with selected other drugs during simulated Y-site co-administration. Physical stability was assessed by both visual observation and turbidity measurement. Micafungin in 0.9% sodium chloride injection was combined with each of 48 other drugs, including antineoplastics, analgesics, anti-infectives, and supportive care drugs undiluted or diluted in 0.9% sodium chloride injection, and with a parenteral nutrition admixture. Visual examinations were performed with the unaided eye in fluorescent light and by using a Tyndall beam, and the turbidity of each sample was measured. The samples were evaluated immediately after mixing and again 1 and 4 hours after preparation. Twenty nine of the drugs tested were found to be compatible for at least 4 hours. The measured turbidity of the micafungin control solutions and the compatible test samples remained essentially unchanged throughout the study. The other 19 drugs exhibited fra

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