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Autologous Eye Drops for the Treatment of Dry Eye and Neurotrophic Keratitis

Author(s):  Mixon William, Angelle Patricea (Patsy), Chang Richard I

Issue:  Nov/Dec 2009 - Geriatric Compounding
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Abstract:  Tears—which contain fibronectin, growth factors, and vitamins that support the migration, proliferation, and differentiation of the conjunctival and corneal epithelium—nourish, protect, and refresh the eye. An inadequate tear film produces a variety of symptoms (ocular irritation, itching, burning, eye strain or fatigue, photophobia, a foreign-body sensation, a sharp stabbing pain, blurred vision) that wax and wane in intensity and are characteristic of disorders such as dry eye (keratoconjunctivitis sicca) and neurotrophic keratitis. In patients for whom commercially manufactured eye drops fail to provide relief from the symptoms of those conditions, autologous serum eye drops (plasma eye drops, serum eye drops) have proven very effective. In this report, we examine the results of treating disorders of the ocular surface with eye drops compounded from patients’ own plasma and present case studies that reveal the effects of autologous serum eye drops on the signs and symptoms of both dry eye and neurotrophic

Related Keywords: William Mixon, RPh, MS, FIACP, Patricea (Patsy) Angelle, PD, FACA, FIACP, Richard I. Chang, MD, autologous serum eye drops, tears, eye disorders, ocular irritation, dry eye, keratoconjunctivitis sicca, neurotrophic keratitis, formulation, sterile preparations, ophthalmic preparations

Related Categories: EXCIPIENTS, FORMULATIONS, OPHTHALMICS, STERILE PREPARATIONS, CASE REPORTS

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