Logo - International Journal of Pharmaceutical Compounding

The Stability of Amphotericin B in a Mixture of Fungizone and Optimoist

Author(s):  Kumar Rajesh, Reznik David A, Gupta Ram B, Betageri Guru V

Issue:  Jul/Aug 1998 - Dermatology
View All Articles in Issue

Abstract:  The physical and chemical stability of amphotericin B in a mixture of Fungizone® and Optimoist® was studied. The mixture was prepared by mixing equal volumes of Fungizone and Optimoist. The rate of sedimentation of amphotericin B was evaluated in Fungizone, Fungizone:Optimoist (1:1) and Fungizone:distilled water (1:1) mixture. The chemical stability of amphotericin B in a mixture of Fungizone:Optimoist (1:1) was determined by high-performance liquid chromatography from samples stored at different temperatures. The rate of sedimentation was faster when Fungizone was mixed with distilled water as compared to Optimoist. Amphotericin B was stable for three weeks stored in the refrigerator (4°C) and for three weeks at room temperature (25°C). Fungizone can be diluted with Optimoist for topical application. The mixture should be shaken well before administration in order to disperse any sediment.


Purchase this article for download in electronic PDF format from IJPC at for $35 at:

Search the entire IJPC archive by keyword, topic, or issue at: