Preparation and Evaluation of Sustained Drug Release from Pluronic Polyol Rectal Suppositories
Author(s): Anderson Derick, Amiji Mansoor M
Issue: May/Jun 2001 - The Business of Compounding
View All Articles in Issue
Page(s): 234-237
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Abstract: Suppository dosage forms offer several advantages in drug delivery
and can be compounded in a pharmacy setting for the
needs of the individual patient. In this study, we have examined
the use of Pluronic polyols in the development of sustainedrelease
rectal suppository formulations. Solid and liquid Pluronic
polyols (Pluronic L61, F68, L101, and F108) were combined
in a weight ratio ranging from 80:20 (solid to liquid) to
70:30 to prepare the bases. The release behavior of a model drug,
riboflavin, from the suppositories was evaluated by means of
the United States Pharmacopeia Basket Dissolution Method.
When compared with the control Polybase suppository, which
released 50% of the drug (t50) in about 7.23 minutes, Pluronic
F68/L61 suppositories at an 80:20 weight ratio exhibited a
t50 of 86.5 minutes (1.44 hours). Riboflavin release from suppositories
made with Pluronic F108/L101 was even further
delayed. The t50 of riboflavin from Pluronic F108/L101 suppositories
at an 80:20 weight ratio, for instance, was 274.4
minutes (4.6 hours). The results of this study show that by choosing
specific combinations of Pluronic polyols and weight ratios,
compounding pharmacists can prepare sustained-release suppository
formulations that can deliver drugs within minutes to
hours. This flexibility of compounding sustained-release suppositories
is beneficial, especially for the management of chronic
pain in cancer patients.
Related Keywords:
Pluronic polyol rectal suppositories, preparation of, Pluronic polyol rectal suppositories, sustained drug release from, Suppositories, rectal, Pluronic polyol
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