Stability of Albuterol in Continuous Nebulization
Author(s): Hunter Dee A, Yoo Sun D, Fox Janet L, Michniak Bozena B
Issue: Sep/Oct 1998 - Parenteral Nutrition Solutions
View All Articles in Issue
Page(s): 394-396
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Abstract: Due to the emergent nature of situations requiring continuous
nebulization of albuterol, a premixed albuterol solution
would provide faster access to the therapy when required.
The purpose of this study was to evaluate the stability of albuterol
solutions at a concentration (200 µg/mL) used in continuous
nebulization when stored in various containers of
polyvinyl chloride bags, polyolefin bags, polypropylene syringes
and tubes and borosilicate glass tubes. Solutions were prepared
in triplicate in 0.9% sodium chloride stored under refrigerated
and room temperatures for seven days. Samples were removed
and analyzed using a stability-indicating high-performance
liquid chromatography assay method. Albuterol was found to
be stable (>90% of the initial concentration remaining) for at
least seven days in all five types of containers under the conditions
tested.
Related Keywords:
Asthma, Fenoterol, Hplc
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