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Stability of Albuterol in Continuous Nebulization

Author(s):  Hunter Dee A, Yoo Sun D, Fox Janet L, Michniak Bozena B

Issue:  Sep/Oct 1998 - Parenteral Nutrition Solutions
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Abstract:  Due to the emergent nature of situations requiring continuous nebulization of albuterol, a premixed albuterol solution would provide faster access to the therapy when required. The purpose of this study was to evaluate the stability of albuterol solutions at a concentration (200 µg/mL) used in continuous nebulization when stored in various containers of polyvinyl chloride bags, polyolefin bags, polypropylene syringes and tubes and borosilicate glass tubes. Solutions were prepared in triplicate in 0.9% sodium chloride stored under refrigerated and room temperatures for seven days. Samples were removed and analyzed using a stability-indicating high-performance liquid chromatography assay method. Albuterol was found to be stable (>90% of the initial concentration remaining) for at least seven days in all five types of containers under the conditions tested.

Related Keywords: Asthma, Fenoterol, Hplc


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