Abstract

Problems of Antibiotic Resistance in Sepsis in Intensive Care Units: A Review of Current Research

Author(s): Królak-Ulinska Aneta, Merks Piotr, Sierzputowska Beata, Sierzputowski Tomasz, Zaychenko Ganna

Issue: Sep/Oct 2025 - Volume 29, Number 5

Page(s): 351-365

Download in electronic PDF format for $75
  • Problems of Antibiotic Resistance in Sepsis in Intensive Care Units: A Review of Current Research Page 1
  • Problems of Antibiotic Resistance in Sepsis in Intensive Care Units: A Review of Current Research Page 2
  • Problems of Antibiotic Resistance in Sepsis in Intensive Care Units: A Review of Current Research Page 3
  • Problems of Antibiotic Resistance in Sepsis in Intensive Care Units: A Review of Current Research Page 4
  • Problems of Antibiotic Resistance in Sepsis in Intensive Care Units: A Review of Current Research Page 5
  • Problems of Antibiotic Resistance in Sepsis in Intensive Care Units: A Review of Current Research Page 6
  • Problems of Antibiotic Resistance in Sepsis in Intensive Care Units: A Review of Current Research Page 7
  • Problems of Antibiotic Resistance in Sepsis in Intensive Care Units: A Review of Current Research Page 8
  • Problems of Antibiotic Resistance in Sepsis in Intensive Care Units: A Review of Current Research Page 9
  • Problems of Antibiotic Resistance in Sepsis in Intensive Care Units: A Review of Current Research Page 10
  • Problems of Antibiotic Resistance in Sepsis in Intensive Care Units: A Review of Current Research Page 11
  • Problems of Antibiotic Resistance in Sepsis in Intensive Care Units: A Review of Current Research Page 12
  • Problems of Antibiotic Resistance in Sepsis in Intensive Care Units: A Review of Current Research Page 13
  • Problems of Antibiotic Resistance in Sepsis in Intensive Care Units: A Review of Current Research Page 14
  • Problems of Antibiotic Resistance in Sepsis in Intensive Care Units: A Review of Current Research Page 15

Abstract

The relevance of antibiotic resistance in intensive care units (ICU) is of great concern because of the growing threat to patient and health care system health. The aim of the study is to comprehensively analyse the prevalence, risk factors, clinical implications and strategies to combat antibiotic resistance in sepsis. Methods include a systematic literature review and evaluation of the effectiveness of different approaches based on empirical evidence. Alarming levels of resistance to reserve-line antibiotics have been observed among Gram-negative pathogens in ICU. Irrational use of antibiotics, lack of adherence to infection control measures and limited implementation of antimicrobial stewardship programmes are key factors contributing to the development and spread of resistance. Infections caused by resistant pathogens are associated with increased mortality, risk of complications, longer hospitalization and higher treatment costs. This creates a situation where opportunities for effective antibiotic therapy become exhausted. Sepsis caused by resistant pathogens significantly complicates treatment and worsens prognosis, increasing the risk of complications and mortality. Overcoming the problem of antibiotic resistance requires a comprehensive approach that includes the development of new antibiotics, rational use of existing drugs, strengthening infection control measures, improving epidemiological surveillance and exploring alternative therapeutic strategies. Antibiotic stewardship programmes (ASPs), infection control measures and combined strategies have demonstrated the greatest effectiveness in combating the spread of resistance in ICU. This study contributes to the understanding of the magnitude of the antibiotic resistance problem and offers specific recommendations for improving clinical practice and health policy.

Related Keywords

  • systemic inflammatory response
  • medications
  • antibacterial drugs
  • prolonged hospitalization
  • Staphylococcus aureus
  • Pseudomonas bacillus

Related Categories

  • DERMATOLOGY
  • WOUND CARE
  • HOSPITAL PHARMACY
  • INFECTIOUS DISEASE

Printer-Friendly Version

Related Articles from IJPC

Issue/Page
View/Buy		 Title/Author
(Click for Abstract / Details / Purchase)
Sep/Oct 2025
Pg. 351-365
Problems of Antibiotic Resistance in Sepsis in Intensive Care Units: A Review of Current Research
Author(s): Królak-Ulinska Aneta, Merks Piotr, Sierzputowska Beata, Sierzputowski Tomasz, Zaychenko Ganna
Mar/Apr 2003
Pg. 106-113
Veterinary Transdermal Medications: A to Z
Author(s): Davidson Gigi S
Jul/Aug 2016
Pg. 328-332
Y-site Physical Compatibility of Beta-blocker Infusions with Intensive Care Unit Admixtures
Author(s): Foushee Jaime A, Meredith Pmichaele, Fox Laura M, Grace EdwardE
Jul/Aug 2016
Pg. 333-337
Evaluation of the Antibacterial Activity of Green Propolis Extract and Meadowsweet Extract Against Staphylococcus aureus Bacteria: Importance in Would Care Compounding Preparations
Author(s): Lupatini Nogueira Rodrigo José, Danopoulos Panagiota, Swikidisa Rosita, Alves Pinheiro Vanessa
Mar/Apr 2019
Pg. 163-166
Evaluation of the Physicochemical Stability of Amiodarone Hydrochloride in Syringes for the Intensive Care Unit
Author(s): Lardinois Benjamin, Dimitriou Alexandre, Delcave Charlotte, Jamart Jacques, Bihin Benoît, Soumoy Laura, Hecq Jean-Daniel, Galanti Laurence M
Jan/Feb 2016
Pg. 58-62
Antimicrobial Activity of Copaiba (Copaifera officinalis) and Pracaxi (Pentaclethra macroloba) Oils against Staphylococcus aureus: Importance in Compounding for Wound Care
Author(s): Guimarães Anna Luísa Aguiar, Cunha Elisa Alves, Matias Fernanda Oliveira, Garcia Patrícia Guedes, Danopoulos Panagiota, Swikidisa Rosita, Pinheiro Vanessa Alves, Nogueira Rodrigo José Lupatini
Mar/Apr 2004
Pg. 101-105
Pluronic Lecithin Organogel for Local Delivery of Anti-Inflammatory Drugs
Author(s): Frankum James, Ramsay Dale, Das Nandita G, Das Sudip K
Jul/Aug 2002
Pg. 245-249
A Review of Current Research on the Effects of Progesterone
Author(s): Boomsma Diane, Jim Paoletti
Jul/Aug 2019
Pg. 320-323
Long-term Physicochemical Stability of Concentrated Solutions of Sodium Valproate in Polypropylene Syringes for Administration in the Intensive Care Unit
Author(s): Lardinois Benjamin, Baltzis Alexandre, Braibant Maximilien, Soumoy Laura, Jamart Jacques, Bihin Benoît, Hecq Jean-Daniel, Galanti Laurence
Jul/Aug 2018
Pg. 335-339
Long-term Physicochemical Stability of Concentrated Solutions of Noradrenaline Bitartrate in Polypropylene Syringes for Administration in the Intensive Care Unit
Author(s): Lardinois Benjamin, Pector Johan, Delcave Charlotte, Soumoy Laura, Jamart Jacques, Bihin B, Hecq Jean-Daniel, Galanti Laurence M
Mar/Apr 2009
Pg. 120-124
Treating Methicillin-Resistant Staphylococcus Aureus Infections with Compounded Vancomycin Preparations
Author(s): McElhiney Linda F
May/Jun 1999
Pg. 225
Veterinary Antibiotic/Antifungal/Anti-Inflammatory Anesthetic Otic Drop
Author(s): Allen Loyd V Jr
Nov/Dec 2002
Pg. 423
Excerpts from and Reviews of Current Published Literature: Pediatric Medications
Author(s): Foy Elizabeth, MacCara Mary E
May/Jun 2004
Pg. 185
Veterinary Antibiotic/Antifungal/Anti-Inflammatory Anesthetic Otic Drops
Author(s): Hinkle Amanda R, Newton Gail D
Jan/Feb 2018
Pg. 19-24
Pain: Systematic Review of Pharmacy Compounding of Pain Medication
Author(s): Shawaqfeh Mohammad S, Harrington Catherine
Nov/Dec 2021
Pg. 446-462
Microwave Freeze-thaw Technique for Injectable Drugs: A Review Updated from 1980 to 2021
Author(s): Hecq Jean-Daniel, Soumoy Laura, Closset Mélanie, Colsoul Marie-Lise, Jamart Jacques, Galanti Laurence
May/Jun 2013
Pg. 254-261
Physiochemical Compatibility of Nebulizable Drug Admixtures Containing Budesonide and Colistmethate or Hypertonic Saline
Author(s): Klemmer Anja, Krämer Irene, Kamin Wolfgang
May/Jun 2014
Pg. 190-200
Compounded Drugs of Value in Outpatient Hospice and Palliative Care Practice
Author(s): McNulty John P, Muller George
Sep/Oct 2010
Pg. 366-369
Community Pharmacy Addresses the Need for Proper Drug Disposal with Positive Response
Author(s): Briggs Valerie
Mar/Apr 2025
Pg. 96-103
Current Problems of Pharmaceutical Compounding in Hungary
Author(s): Dobson Szabolcs