Sterile Basics: Intravenous Admixture Compounding, Part 1: Introduction and Overview of the General Guidelines for an Intravenous Admixture Compounding Program, and Compounding Personnel Considerations
Author(s): Allen Loyd V Jr
Issue: Mar/Apr 2023 - Volume 27, Number 2
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Abstract: Intravenous admixture compounding is a common practice in most hospitals throughout the world, regardless of the country. Due to the complexity in compounding intravenous medications, there is a high potential for error, and since intravenous medications must be compounded in an aseptic environment, this poses additional issues for the compounder. Part 1 of this series of articles provides an introduction, an overview, and compounding personnel considerations of this topic. The remaining parts of this series will cover parenteral vehicle considerations; preparation procedures; physicochemical considerations; handling potential incompatibilities; endotoxin considerations; and quality control of intravenous admixtures. This introductory article in this overall series on intravenous admixture preparation presents issues related to their compounding and to medication error prevention.
Related Keywords: intravenous admixtures, hospital pharmacy, compounded sterile preparations, aseptic technique, compounding personnel, drug errors, commercial products, contamination, incompatibility, chemical stability, United States Pharmacopeia Chapter <797>, USP, drug safety, microbial contaminants, bacterial endotoxins, patient-controlled analgesia, quality control, small-volume injections, large-volume parenterals, infusions, maintenance therapy, electrolyte replacement, total parenteral nutrition, cleanroom processes, standardization of intravenous concentrations
Related Categories: PARENTERALS, STERILE PREPARATIONS, QUALITY CONTROL, UNITED STATES PHARMACOPEIA CONVENTIONS, HOSPITAL PHARMACY, INFORMATION RESOURCES
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