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Sterile Basics: Intravenous Admixture Compounding, Part 1: Introduction and Overview of the General Guidelines for an Intravenous Admixture Compounding Program, and Compounding Personnel Considerations

Author(s):  Allen Loyd V Jr

Issue:  Mar/Apr 2023 - Volume 27, Number 2
View All Articles in Issue

Page(s):  123-139

Sterile Basics: Intravenous Admixture Compounding, Part 1: Introduction and Overview of the General Guidelines for an Intravenous Admixture Compounding Program, and Compounding Personnel Considerations Page 1
Sterile Basics: Intravenous Admixture Compounding, Part 1: Introduction and Overview of the General Guidelines for an Intravenous Admixture Compounding Program, and Compounding Personnel Considerations Page 2
Sterile Basics: Intravenous Admixture Compounding, Part 1: Introduction and Overview of the General Guidelines for an Intravenous Admixture Compounding Program, and Compounding Personnel Considerations Page 3
Sterile Basics: Intravenous Admixture Compounding, Part 1: Introduction and Overview of the General Guidelines for an Intravenous Admixture Compounding Program, and Compounding Personnel Considerations Page 4
Sterile Basics: Intravenous Admixture Compounding, Part 1: Introduction and Overview of the General Guidelines for an Intravenous Admixture Compounding Program, and Compounding Personnel Considerations Page 5
Sterile Basics: Intravenous Admixture Compounding, Part 1: Introduction and Overview of the General Guidelines for an Intravenous Admixture Compounding Program, and Compounding Personnel Considerations Page 6
Sterile Basics: Intravenous Admixture Compounding, Part 1: Introduction and Overview of the General Guidelines for an Intravenous Admixture Compounding Program, and Compounding Personnel Considerations Page 7
Sterile Basics: Intravenous Admixture Compounding, Part 1: Introduction and Overview of the General Guidelines for an Intravenous Admixture Compounding Program, and Compounding Personnel Considerations Page 8
Sterile Basics: Intravenous Admixture Compounding, Part 1: Introduction and Overview of the General Guidelines for an Intravenous Admixture Compounding Program, and Compounding Personnel Considerations Page 9
Sterile Basics: Intravenous Admixture Compounding, Part 1: Introduction and Overview of the General Guidelines for an Intravenous Admixture Compounding Program, and Compounding Personnel Considerations Page 10
Sterile Basics: Intravenous Admixture Compounding, Part 1: Introduction and Overview of the General Guidelines for an Intravenous Admixture Compounding Program, and Compounding Personnel Considerations Page 11
Sterile Basics: Intravenous Admixture Compounding, Part 1: Introduction and Overview of the General Guidelines for an Intravenous Admixture Compounding Program, and Compounding Personnel Considerations Page 12
Sterile Basics: Intravenous Admixture Compounding, Part 1: Introduction and Overview of the General Guidelines for an Intravenous Admixture Compounding Program, and Compounding Personnel Considerations Page 13
Sterile Basics: Intravenous Admixture Compounding, Part 1: Introduction and Overview of the General Guidelines for an Intravenous Admixture Compounding Program, and Compounding Personnel Considerations Page 14
Sterile Basics: Intravenous Admixture Compounding, Part 1: Introduction and Overview of the General Guidelines for an Intravenous Admixture Compounding Program, and Compounding Personnel Considerations Page 15
Sterile Basics: Intravenous Admixture Compounding, Part 1: Introduction and Overview of the General Guidelines for an Intravenous Admixture Compounding Program, and Compounding Personnel Considerations Page 16
Sterile Basics: Intravenous Admixture Compounding, Part 1: Introduction and Overview of the General Guidelines for an Intravenous Admixture Compounding Program, and Compounding Personnel Considerations Page 17

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Abstract:  Intravenous admixture compounding is a common practice in most hospitals throughout the world, regardless of the country. Due to the complexity in compounding intravenous medications, there is a high potential for error, and since intravenous medications must be compounded in an aseptic environment, this poses additional issues for the compounder. Part 1 of this series of articles provides an introduction, an overview, and compounding personnel considerations of this topic. The remaining parts of this series will cover parenteral vehicle considerations; preparation procedures; physicochemical considerations; handling potential incompatibilities; endotoxin considerations; and quality control of intravenous admixtures. This introductory article in this overall series on intravenous admixture preparation presents issues related to their compounding and to medication error prevention.

Related Keywords: Loyd V. Allen Jr., PhD, RPh, intravenous admixtures, hospital pharmacy, compounded sterile preparations, aseptic technique, compounding personnel, drug errors, commercial products, contamination, incompatibility, chemical stability, United States Pharmacopeia Chapter <797>, USP, drug safety, microbial contaminants, bacterial endotoxins, patient-controlled analgesia, quality control, small-volume injections, large-volume parenterals, infusions, maintenance therapy, electrolyte replacement, total parenteral nutrition, cleanroom processes, standardization of intravenous concentrations

Related Categories: PARENTERALS, STERILE PREPARATIONS, QUALITY CONTROL, UNITED STATES PHARMACOPEIA CONVENTIONS, HOSPITAL PHARMACY, INFORMATION RESOURCES

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