Stability of Dobutamine Hydrochloride 4 mg/mL in 5% Dextrose Injection at 5 and 23 degrees C
Author(s): Webster Andrew A, English Brett A, McGuire J Michael, Riggs Robert M, Lander Vickie, Buckle Thomas
Issue: Sep/Oct 1999 - Natural Hormone Replacement Therapy
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Page(s): 412-414
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Abstract: The stability of dobutamine hydrochloride 4 mg/mL in 5%
dextrose injection has been studied using a stability-indicating,
high-performance liquid chromatography assay method.
The admixture injections were stable for 30 days at 5 and 23°C.
Concentrations ranged between 98.5% and 102.6% for the
room-temperature samples, and 99.6% and 101.8% for the refrigerated
samples, of the initial mean concentrations. The
standard curves demonstrated linearity (r2>.999). Variations
within and between days were less than 3%. None of the samples
appeared to form a visible precipitate or changed in color
or clarity and the pH of the samples remained between 3.5
and 3.7.
Related Keywords:
dextrose, dobutamine hydrochloride, injection, pH, precipitate, stability
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