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Extemporaneous Lozenge Formulations

Author(s):  Palmer Henry A, Semprebon Marc

Issue:  Jan/Feb 1998 - Hormone Replacement
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Page(s):  71-72

Extemporaneous Lozenge Formulations Page 1
Extemporaneous Lozenge Formulations Page 2

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Abstract:  The authors describe their method of compounding a slowly dissolving pilocarpine lozenge to be used to treat xerostomia. They began by formulating a series of lozenges, initially without drug, to determine consistency and pursued the problem of molding each individual lozenge. They used a formula for glycerinated gelatin suppositories as a starting point. They provide a table of trial formulas of placebo lozenges, to which active drug , if it is water soluble, could be easily dissolved in the aqueous phase when the mix is relatively cool (or stirred in, producing a slurry, just before congealing).

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