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The Formulation Development and Stability of Metronidazole Suspension

Author(s):  Alexander Kenneth S, Vangala Shyam Sundar KS, Dollimore David

Issue:  May/Jun 1997 - Geriatric Care
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Abstract:  The purpose of this study was to extemporaneously formulate a liquid dosage form from commercially available tablets and establish the chemical stability of the drug. A suspension of metronidazole (15 mg/mL) was formulated from 500-mg metronidazole tablets. Stability-indicating, high-performance liquid chromatography assay procedures were utilized to analyze the concentration of the drug. Chemical stability was predicted using accelerated stability studies conducted at four temperatures, namely, 40°, 50°, 60° and 70°C for metronidazole. The Arrhenius plot was used to predict the shelf-life of the metronidazole suspension at room temperature. The shelflife was calculated from the initial concentration and ko was found to be 73 years. However, it would be more reasonable to expect that a quantity lasting no more than 90 days should be prepared and dispensed.

Related Categories: PEDIATRICS, PEER-REVIEWED, STABILITIES, COMPATIBILITIES

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