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Abstract:  The physical and chemical stability of preservativefree meperidine hydrochloride solutions in polypropylene syringes was studied. Solutions of meperidine hydrochloride were diluted in dextrose 5% and normal saline to 0.25, 1, 10, 20 and 30 mg/mL, respectively, and stored at either 22°C or 4°C for 28 days. All solutions were protected from light during storage. Triplicate samples were taken from each syringe on days zero, one, three, seven, 14 and 28 and frozen at -72°C. Samples were analyzed in duplicate using a stability- indicating high-pressure liquid chromatography assay. All samples remained colorless and free of precipitate throughout the course of the study. The concentration of meperidine remaining after the 28-day storage period was greater than 90% of the initial concentration for all the concentrations, diluents and temperatures studied.

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