Stability of an Oral Liquid Dosage Form of Glycopyrrolate Prepared from Tablets
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Abstract: A stability-indicating assay method has been developed to quantify
glycopyrrolate in an oral liquid dosage form. The developed
method is accurate and precise and has a percent relative
standard deviation of 1.8 based on 5 injections. The decomposition
product and the excipients present in the dosage form
did not interfere with the assay procedure. An oral liquid
dosage form (0.5 mg/mL in water) that was prepared using 1-
mg commercially available tablets was stable for 25 days (loss
in potency, 8.2%). During that time, the pH value of the dosage
form decreased from 6.8 to 6.6.
Related Keywords:
Glycopyrrolate, oral liquid, stability of
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