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Stability of an Oral Liquid Dosage Form of Glycopyrrolate Prepared from Tablets

Author(s):  Gupta Vishnu D

Issue:  Nov/Dec 2001 - High-Tech Compounding
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Abstract:  A stability-indicating assay method has been developed to quantify glycopyrrolate in an oral liquid dosage form. The developed method is accurate and precise and has a percent relative standard deviation of 1.8 based on 5 injections. The decomposition product and the excipients present in the dosage form did not interfere with the assay procedure. An oral liquid dosage form (0.5 mg/mL in water) that was prepared using 1- mg commercially available tablets was stable for 25 days (loss in potency, 8.2%). During that time, the pH value of the dosage form decreased from 6.8 to 6.6.

Related Keywords: Glycopyrrolate, oral liquid, stability of


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