Stability of Neostigmine Methylsulfate Injection at Ambient Temperature and 4°C in Polypropylene Syringes
Author(s): Storms Meredith L, Stewart James T, Warren Flynn W
Issue: Nov/Dec 2002 - Sterile Preparations and Pediatric Compounding
View All Articles in Issue
Page(s): 475-477
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Abstract: The stability of 1.0-mg/mL neostigmine methylsulfate injection
in 6-mL polypropylene syringes stored at ambient
temperature under continuous fluorescent light and at 4°C
for up to 90 days was investigated. Concentration levels of
neostigmine methylsulfate injection were determined at 0,
1, 4, 7, 15, 30, 45, 60, and 90 days after preparation of the
syringes by means of a high-performance liquid chromatographic
stability-indicating assay. Phenol, which was present
as a preservative in the injection, did not interfere with
the assay. The injections in plastic syringes were stable for
up to 90 days at both ambient temperature and at 4°C. The
pH of neostigmine methylsulfate injection did not change appreciably
over the 90-day study period. These data support
the stability of neostigmine methylsulfate injection under the
storage conditions investigated in this study.
Related Keywords:
Neostigmine methylsulfate injection, effect of temperature on stability of, Neostigmine methylsulfate injection, stability of, in prefilled polypropylene syringes
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