Stability of Neostigmine Methylsulfate Injection at Ambient Temperature and 4°C in Polypropylene Syringes
Author(s): Storms Meredith L, Stewart James T, Warren Flynn W
Issue: Nov/Dec 2002 - Sterile Preparations and Pediatric Compounding
View All Articles in Issue
Page(s): 475-477
Download in electronic PDF format for $65
Abstract: The stability of 1.0-mg/mL neostigmine methylsulfate injection
in 6-mL polypropylene syringes stored at ambient
temperature under continuous fluorescent light and at 4°C
for up to 90 days was investigated. Concentration levels of
neostigmine methylsulfate injection were determined at 0,
1, 4, 7, 15, 30, 45, 60, and 90 days after preparation of the
syringes by means of a high-performance liquid chromatographic
stability-indicating assay. Phenol, which was present
as a preservative in the injection, did not interfere with
the assay. The injections in plastic syringes were stable for
up to 90 days at both ambient temperature and at 4°C. The
pH of neostigmine methylsulfate injection did not change appreciably
over the 90-day study period. These data support
the stability of neostigmine methylsulfate injection under the
storage conditions investigated in this study.
Related Keywords:
Neostigmine methylsulfate injection, effect of temperature on stability of, Neostigmine methylsulfate injection, stability of, in prefilled polypropylene syringes
| Related Articles from IJPC |
Title/Author
(Click for Abstract / Details / Purchase) |
Issue/Page
View/Buy |
Stability of Neostigmine Methylsulfate Injection at Ambient Temperature and 4°C in Polypropylene Syringes
Storms Meredith L, Stewart James T, Warren Flynn W
|
Nov/Dec 2002
Pg. 475-477
|
Neostigmine Methylsulfate 0.5-mg/mL Injection
Allen Loyd V Jr
|
Jan/Feb 2013
Pg. 70
|
Stability of Lidocaine Hydrochloride Injection at Ambient Temperature and 4°C in Polypropylene Syringes
Storms Meredith L, Stewart James T, Warren Flynn W
|
Sep/Oct 2002
Pg. 388-390
|
Stability of Glycopyrrolate Injection at Ambient Temperature and 4°C in Polypropylene Syringes
Storms Meredith L, Stewart James T, Warren Flynn W
|
Jan/Feb 2003
Pg. 65-67
|
Stability of Succinylcholine Chloride Injection at Ambient Temperature and 4 Degree C in Polypropylene Syringes
Storms Meredith L, Stewart James T, Warren Flynn W
|
Jan/Feb 2003
Pg. 68-70
|
Stability of Tubocurarine Chloride Injection at Ambient Temperature and 4°C in Polypropylene Syringes
Stewart James T, Storms Meredith L, Warren Flynn W
|
Jul/Aug 2002
Pg. 308-310
|
Stability of Aminocaproic Acid Injection Admixtures in 5% Dextrose Injection and 0.9% Sodium Chloride Injection
Zhang Yan-ping, Trissel Lawrence A
|
Mar/Apr 1997
Pg. 132-134
|
Stability of Levothyroxine Sodium Injection in Polypropylene Syringes
Gupta Vishnu D
|
Nov/Dec 2000
Pg. 482-483
|
Physical and Chemical Stability of Palonosetron Hydrochloride with Glycopyrrolate and Neostigmine During Simulated Y-Site Administration
Ben Michel, Trusley Craig, Kupiec Thomas C, Trissel Lawrence A
|
Jul/Aug 2008
Pg. 368-371
|
Stability of Furosemide 5 mg/mL in Polypropylene Syringes
van der Schaar JAJ, Grouls R, Franssen EJF, Crul M
|
Sep/Oct 2019
Pg. 414-417
|
