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Compatibility of Vancomycin Hydrochloride and Famotidine in 5% Dextrose Injection

Author(s):  Wang De-Peng, Wang Meng-Ting, Wong Chi-Yin, Lee Derek KT

Issue:  Sep/Oct 1997 - Home Health Care
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Abstract:  The compatibility of vancomycin hydrochloride and famotidine in 5% dextrose injection stored at two temperatures was studied.

Vancomycin hydrochloride and famotidine were reconstituted and diluted with 5% dextrose injection to form an admixture with a famotidine concentration of 0.2 mg/mL and a vancomycin concentration of 5 mg/mL. The admixture was stored in 100-mL vented intravenous containers in the dark at 4 and 25°C; three containers were stored at each temperature. A 2-mL sample was taken from each container after six and 12 hours and 1, 3, 5, 7, 10, 12 and 14 days of storage and visually inspected, tested for pH and assayed by a developed stabilityindicating high performance liquid chromatographic method. Triplicate samples were prepared for each storage condition.

No color change, precipitation or cloudiness was observed in any sample at any time during the study.

Vancomycin 5 mg/mL and famotidine 0.2 mg/mL in admixtures in 5% dextrose injection are stable for 14 days at 4 and 25°C.


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