Stability of Lisinopril Syrup (2 mg/mL) Extemporaneously Compounded from Tablets
Author(s): Rose Deidra J, Webster Andrew A, English Brett A, McGuire J Michael
Issue: Sep/Oct 2000 - Compounding for Immune System Disorders
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Page(s): 398-399
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Abstract: The stability of lisinopril syrup (2 mg/mL) extemporaneously compounded from
tablets was investigated. Zestril® tablets (Lot CSC201, Zeneca Pharmaceuticals,
Wilmington, Del) were crushed, dissolved in water, filtered, and diluted with syrup
NF to a final nominal concentration of 2 mg/mL. The solution was then equally
divided among amber-colored prescription bottles and was stored at 5°C and 23°C.
During the 30-day study period, samples were extracted by means of a water:methanol
mix, and the concentration of lisinopril was determined by a stability-indicating, highperformance
liquid chromatography assay procedure. Stability was also determined
by pH measurements and visual inspection for color or clarity change. Over the 30-
day study period, the percentage of the initial lisinopril concentration remained
between 99.42% ± 0.19% and 95.68% ± 1.5% for the 5°C samples and 98.83% ± 0.46%
and 96.48% ± 0.62% for the 23°C samples.
Related Keywords:
lisinopril syrup, stability, liquid lisinopril, storage
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