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Stability of Ephedrine Sulfate at Ambient Temperature and 4°C in Polypropylene Syringes

Author(s):  Storms Meredith L, Stewart James T, Warren Flynn W

Issue:  Sep/Oct 2001 - Bioidentical Hormone Replacement Therapy
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Page(s):  394-396

Stability of Ephedrine Sulfate at Ambient Temperature and 4°C in Polypropylene Syringes Page 1
Stability of Ephedrine Sulfate at Ambient Temperature and 4°C in Polypropylene Syringes Page 2
Stability of Ephedrine Sulfate at Ambient Temperature and 4°C in Polypropylene Syringes Page 3

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Abstract:  The stability of 5 mg/mL ephedrine sulfate in 0.9% sodium chloride in 10-mL polypropylene syringes stored at ambient temperature and at 4°C for up to 60 days was investigated. Concentration levels of ephedrine sulfate were determined by means of a high-performance liquid chromatography stability-indicating assay at 0, 1, 4, 7, 14, 30, 45, and 60 days after preparation of the syringes. Benzyl alcohol, which was added as a preservative, did not interfere with the assay. The injections in polypropylene syringes were stable for up to 60 days at both ambient temperature and at 4°C. The pH of the ephedrine sulfate injections did not change appreciably in a particular direction during the 60-day study period. These data support the stability of ephedrine sulfate under the storage conditions investigated in this study.

Related Keywords: Ephedrine sulfate, stability of

Related Categories: INFUSION, PEER-REVIEWED, STABILITIES, COMPATIBILITIES

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