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Abstract:  This discussion covers the pathophysiologic factors of Cushing’s disease in dogs, signs and symptoms of canine Cushing’s disease (increased water consumption and urination, increased appetite, abdominal enlargement, alopecia and epidermal atrophy and other signs), diagnosis, treatment, monitoring and prognosis. A list of compounds potentially useful in the diagnosis and treatment is provided, along with a list of information helpful to permit importation of an unapproved drug and contact address for the relevant person to contact at the US Food and Drug Administration. The author concludes that compounding pharmacists can greatly contribute to the successful diagnosis, treatment and management of Cushing’s disease by providing products for diagnosis and treatment and by participating actively in patient follow-up during therapy. By fully understanding the pathophysiologic factors and natural history of the disorder, pharmacists can support both owners and veterinarians in the difficult process of managing dogs with this disorder.

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