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Stability of Cefmetazole Sodium in 5% dextrose Injection and 0.9% Sodium Chloride Injection

Author(s):  Gupta Vishnu D, Maswoswe J, Bailey RE

Issue:  May/Jun 1997 - Geriatric Care
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Abstract:  The stability of cefmetazole sodium in 5% dextrose injection and 0.9% sodium chloride injection has been studied using a stability-indicating, high-performance liquid chromatography (HPLC) assay method developed in our laboratory. This HPLC method is precise and accurate, with a percent relative standard deviation of 1.4 based on five readings. The admixtures were stable for two days at 25°C and for 28 days at 5°C, and they remained clear throughout the study period. The pH values decreased from 4.7 to 4.0 in 0.9% sodium chloride injection and from 4.8 to 4.2 in 5% dextrose injection. The expiry date of seven days at 5°C recommended by the manufacturer appears to be conservative from a chemical-stability standpoint.


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