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Stability of Magnesium Sulfate in 0.9% Sodium Chloride and Lactated Ringers Solutions

Author(s):  Sarver Jeffrey G, Pryka Randy, Alexander Kenneth S, Weinstein Louis, Erhardt Paul W

Issue:  Sep/Oct 1998 - Parenteral Nutrition Solutions
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Page(s):  385-388

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Abstract:  Storage stability tests were performed on two extemporaneous formulation alternatives to the commercially available magnesium sulfate injection solutions that are in 5% dextrose or in water. Preparations of the commercial water for injection formulation and two alternative formulations in lactated Ringers and in 0.9% sodium chloride were stored at room temperature in glass bottles and in polyvinyl chloride bags over a three-month period. Solutions were monitored for gross precipitation and for changes in magnesium, sulfur and calcium levels as measured by elemental analysis using atomic absorption spectroscopy and inductively coupled plasma atomic emission spectroscopy. The results demonstrate no consistent decreases in measured elemental concentrations or gross signs of precipitation for any formulation tested.


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