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Physical Stability of Urea Topical Formulations

Author(s):  Allen Loyd V Jr, Li Xiao-Hai

Issue:  May/Jun 1997 - Geriatric Care
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Page(s):  168-171

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Abstract:  Urea is used in concentrations as high as 40% in different vehicles for numerous conditions. The purpose of this study was to observe the physical stability characteristics of urea incorporated into several different dermatological bases. In particular, urea was incorporated, in concentrations ranging from 10% to 40%, into ten different vehicles or vehicle combinations; and the physical characteristics/stability were observed. The preparations with the best observable characteristics and apparent physical stability included Carbopol® and combinations of Carbopol with Velvachol®.

Related Keywords: Aquaphor, Keratolytic, Velvachol, Hydrating, Petrolatum, Carbopol, Lanaphilic


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