Bot Detector
IJPC Seal
Download FREE Sample Issue or Article
LEARN MORE
Subscribe Today
A subscription to IJPC provides on-line access to full-text, full-color, printable PDF copies of your subscribed issues, individual articles, and purchased archives.

Literature Review: The Dual Role of Domperidone in Gastroparesis and Lactation

Author(s):  Phan Ha, DeReese Annie, Day A J, Carvalho Maria

Issue:  May/Jun 2014 - Volume 18, Number 3
View All Articles in Issue

Page(s):  203-207

Literature Review: The Dual Role of Domperidone in Gastroparesis and Lactation Page 1
Literature Review: The Dual Role of Domperidone in Gastroparesis and Lactation Page 2
Literature Review: The Dual Role of Domperidone in Gastroparesis and Lactation Page 3
Literature Review: The Dual Role of Domperidone in Gastroparesis and Lactation Page 4
Literature Review: The Dual Role of Domperidone in Gastroparesis and Lactation Page 5

Download in electronic PDF format for $75

Abstract:  Domperidone is a prokinetic agent used as a second-line treatment option for gastroparesis in those unable to tolerate metoclopramide. Via inhibition of dopamine- 2 receptors within the gastrointestinal tract and various parts of the central and peripheral nervous system, domperidone helps to facilitate peristalsis and gastric emptying. A major side effect of domperidone is prolactinemia, allowing it to be used off-label for the purpose of inducing lactation. In the U.S., domperidone is currently not U.S. Food and Drug Administration approved due to various case reports and literature associating the risks of sudden cardiac death and ventricular arrhythmia with the use of domperidone. Despite the evidence against the use of domperidone, it is still being widely used in Canada and Europe for both gastroparesis and to induce milk let-down. This article is a literature review intending to assess the risks associated with the use of domperidone in gastroparesis and lactation.

Related Keywords: Ha Phan, Annie DeReese, PharmD, RPh, A.J. Day, PharmD, RPh, Maria Calvalho, PharmD, MRPharmS, PhD, domperidone, prokinetic agent, dopamine 2 receptors, prolactinemia, lactation induction, U.S. Food and Drug Administration, FDA, sudden cardiac death, arrhythmia, gastrointestinal motility, prolonged QTc interval, breast milk

Related Categories: GASTROENTEROLOGY, ADVERSE DRUG EVENTS, CARDIOLOGY, ENDOCRINOLOGY/HORMONES/ MENOPAUSE/ANDROPAUSE, LITERATURE REVIEW

Printer-Friendly Version



Related Articles from IJPC
Title/Author
(Click for Abstract / Details / Purchase)
Issue/​Page
View/Buy
Literature Review: The Dual Role of Domperidone in Gastroparesis and Lactation
Phan Ha
, DeReese Annie, Day A J, Carvalho Maria
May/Jun 2014
Pg. 203-207

Domperidone in Lactation: Use as a Galactagogue
Albright Lisa M
Sep/Oct 2004
Pg. 329-335

Use of Domperidone as a Prokinetic and Antiemetic
Albright Lisa M
Mar/Apr 2005
Pg. 120-125

View Sample
Domperidone 5 mg/mL in Oral Mix
Allen Loyd V Jr
Jul/Aug 2019
Pg. 316

Domperidone 5 mg/mL in SyrSpend SF pH4
Allen Loyd V Jr
Nov/Dec 2021
Pg. 500

Wetting and/or Solubilizing Agents, Featured Excipient:
Allen Loyd V Jr
Jul/Aug 2001
Pg. 310-312

Incorporating Quality Assurance in Pharmaceutical Compounding-related Courses in the PharmD Curricula
Hossain Mohammad Faisal
, Levesque Dan, Frye John, Rashid Mamoon
Jul/Aug 2020
Pg. 322-326

Healthful Living: Good Practices for Good Health
Jackson Kathy
May/Jun 2002
Pg. 164-166

Efficacy and Clinical Value of Commonly Used Ingredients in Pain Management Compounds: A Literature Review
Beshay Sarah M
, Rivera Gerard, Balthasar Jan, Florea Naomi
Jul/Aug 2015
Pg. 295-300

Case Report: Diabetic Foot Ulcer Infection Treated with Topical Compounded Medications
Agbi Kelechi E
, Carvalho Maria, Phan Ha, Tuma Cristiane
Jan/Feb 2017
Pg. 22-27

Stability Studies of Fludrocortisone Acetate Capsules and Fludrocortisone Acetate Titrated Powders (Powder Triturates)
Brandin Thibaut
, Wasilewski Maya, Panuccio Camille, Bouguergour Cyrielle, Primas Nicolas, Lamy Edouard, Jean Christophe, Bertault-Peres Pierre, Rathelot Pascal, Curti Christophe, Vanelle Patrice
Mar/Apr 2022
Pg. 150-154

Compounding for Diabetic Patients:An Interview with Paul Lofholm, PharmD
Allen Loyd V Jr
Nov/Dec 1997
Pg. 381-385

Rapid-Dissolve Technology: An Interview With Loyd V. Allen, Jr., PhD, RPh
Allen Loyd V Jr
Nov/Dec 2003
Pg. 449-450

Domperidone 1-mg/mL Oral Liquid
Allen Loyd V Jr
Jan/Feb 2006
Pg. 61

Safe Cytotoxic Drug Preparation Using a Closed-system Transfer Device: Technical and Practical Evaluation of a New Device (Vialshield/Texium) Comparatively to a Reference One (Phaseal)
Garrigue Philippe
, Montana Marc, Ventre Christophe, Savry Amadine, Gauthier-Villano Laurence, Pisano Pascale, Pourroy Bertrand
Mar/Apr 2016
Pg. 148-154

Efficacy and Clinical Value of Commonly Compounded Hormone Replacement Therapy: A Literature Review
Beshay Sarah M
, Rivera Gerard, Balthasar Jan, Florea Naomi
Jan/Feb 2015
Pg. 6-12

The Role of Compounding in Closing Therapeutic Gaps--Abstracts from FIP 2013
Lutz Eugene
, Pauletti Giovanni, Carvalho Maria, Davidson Gigi, Ashworth Lisa, Subramaniam Vaiyapuri, LlambĂ­ Francesc
Jan/Feb 2014
Pg. 6-12

Beyond-use Date of Trimix: A Reproducible Stability Study Using Bracketing Design
Patel Gopesh
, Davis Countaney, Liu Yi, Ip Kendice, Debideen Krystal E, Anderson Stephanie, Byrne Robert, Herr Dylan, Rhoads Melissa Merrell, Caputo Ross, Banov Daniel, Bassani August S
Jan/Feb 2021
Pg. 73-81

Compatibility of Flavoring Agents in Compounding Extemporaneous Omeprazole Oral Liquid
Chuong Monica
, Taglieri Catherine A, Huang Szu Yu, Sariol Anthony, Kitigawa Reina, Barman Koushik, Mistry Amee, Harris Donna L, Kerr Stephen G
Nov/Dec 2019
Pg. 504-510

Case Report: Pediatric Scar Management After Open-heart Surgery
Phan Ha
, Harger Beau, Estrada Nick
Jul/Aug 2016
Pg. 277-280

Return to Top