Physical and Chemical Stability of Palonosetron Hydrochloride with Lorazepam and Midazolam Hydrochloride during Simulated Y-Site Administration

Trissel, Lawrence A; Xu, Quanyun A

Abstract

Physical and Chemical Stability of Palonosetron Hydrochloride with Lorazepam and Midazolam Hydrochloride during Simulated Y-Site Administration

Author(s): Trissel Lawrence A, Xu Quanyun A

Issue: May/Jun 2005 - Veterinary Compounding

View All Articles in Issue

Page(s): 235-237

Download in electronic PDF format for $75

Abstract

The objective of this study was to evaluate the physical and chemical stability of undiluted palonosetron hydrochloride 50 µg/mL in combination with lorazepam 0.5 mg/mL or midazolam hydrochloride 2 mg/mL in 5% dextrose injection during simulated Y-site administration. Triplicate test samples were prepared by admixing 5 mL of palonosetron hydrochloride with 5 mL of the lorazepam or midazolam hydrochloride admixture. Physical stability was assessed by using a multistep evaluation procedure that included both turbidimetric and particulate measurements as well as visual inspection. Chemical stability was assessed by using stability-indicating high-performance liquid chromatographic analytical techniques that determined drug concentrations. Evaluations were performed initially upon mixing and again 1 and 4 hours after mixing. The samples were clear and colorless when viewed in normal fluorescent room light and when viewed with a Tyndall beam. Measured turbidity remained unchanged; particulate content was low and changed little. High-performance liquid chromatographic analysis revealed that palonosetron hydrochloride, lorazepam, and midazolam hydrochloride remained stable throughout the 4-hour test with no drug loss. Palonosetron hydrochloride is physically compatible and chemically stable with lorazepam or midazolam hydrochloride during Y-site administration.

Related Keywords

Related Categories

Printer-Friendly Version

Related Articles from IJPC

Issue/Page View/Buy	Title/Author (Click for Abstract / Details / Purchase)
May/Jun 2005 Pg. 235-237	Physical and Chemical Stability of Palonosetron Hydrochloride with Lorazepam and Midazolam Hydrochloride during Simulated Y-Site Administration Author(s): Trissel Lawrence A, Xu Quanyun A
Mar/Apr 2008 Pg. 170-173	Compatibility and Stability of Palonosetron Hydrochloride with Gentamicin, Metronidazole, or Vancomycin During Simulated Y-Site Administration Author(s): Kupiec Thomas C, Ben Michel, Trusley Craig, Trissel Lawrence A
Mar/Apr 2008 Pg. 156-160	Compatibility and Stability of Palonosetron Hydrochloride with Four Neuromuscular Blocking Agents During Simulated Y-Site Administration Author(s): Trusley Craig, Ben Michel, Kupiec Thomas C, Trissel Lawrence A
Jul/Aug 2008 Pg. 368-371	Physical and Chemical Stability of Palonosetron Hydrochloride with Glycopyrrolate and Neostigmine During Simulated Y-Site Administration Author(s): Ben Michel, Trusley Craig, Kupiec Thomas C, Trissel Lawrence A
May/Jun 2005 Pg. 238-241	Physical and Chemical Stability of Palonosetron Hydrochloride with Topotecan Hydrochloride and Irinotecan Hydrochloride during Simulated Y-Site Administration Author(s): Trissel Lawrence A, Xu Quanyun A
Nov/Dec 2007 Pg. 520-524	Palonosetron Hydrochloride Compatibility and Stability with Three Beta-Lactam Antibiotics During Simulated Y-Site Administration Author(s): Ben Michel, Trusley Craig, Kupiec Thomas C, Trissel Lawrence A
Jan/Feb 2009 Pg. 78-80	Compatibility and Stability of Palonosetron Hydrochloride and Propofol During Simulated Y-Site Administration Author(s): Trissel Lawrence A, Trusley Craig, Kupiec Thomas C, Ben Michel
Sep/Oct 2008 Pg. 460-462	Compatibility and Stability of Palonosetron Hydrochloride with Lactated Ringer's, Hetastarch in Lactated Electrolyte, and Mannitol Injections During Simulated Y-Site Administration Author(s): Ben Michel, Kupiec Thomas C, Trusley Craig, Trissel Lawrence A
Jul/Aug 2005 Pg. 320-322	Physical and Chemical Stability of Palonosetron Hydrochloride with Fluorouracil and with Gemcitabine Hydrochloride during Simulated Y-site Administration Author(s): Trissel Lawrence A, Zhang Yanping
Jan/Feb 2007 Pg. 82-85	Physical and Chemical Stability of Palonosetron with Metoclopramide and Promethazine During Simulated Y-Site Administration Author(s): Trusley Craig, Ben Michel, Kupiec Thomas C, Trissel Lawrence A
Jan/Feb 2017 Pg. 76-82	Compatibility and Stability of Rolapitant Injectable Emulsion Admixed with Intravenous Palonosetron Hydrochloride Author(s): Wu George, Yeung Stanley, Chen Frank
May/Jun 2006 Pg. 234-236	Physical and Chemical Stability of Palonosetron Hydrochloride with Dacarbazine and with Methylprednisolone Sodium Succinate During Simulated Y-Site Administration Author(s): Trissel Lawrence A, Xu Quanyun A, Zhang Yanping
May/Jun 1999 Pg. 235-238	Fosphenytoin Y-site Stability Studies with Lorazepam and Midazolam Hydrochloride Author(s): Riggs Robert M, English Brett A, Webster Andrew A, McGuire J Michael, Riordan James M, Worthington Mary A
Jan/Feb 2018 Pg. 76-85	Compatibility and Stability of VARUBI (Rolapitant) Injectable Emulsion Admixed with Intravenous Palonosetron Hydrochloride Injection and Dexamethasone Sodium Phosphate Injection Author(s): Wu George, Powers Dan, Yeung Stanley, Chen Frank
Jan/Feb 1998 Pg. 79-82	Physical Compatibility and Chemical Stability of Atracurium Besylate and Midazolam Hydrochloride during Intravenous Coinfusion Author(s): Bhatt-Mehta Varsha, Hirata Stacy
Jan/Feb 2002 Pg. 66-69	Physical and Chemical Stability of Low and High Concentrations of Morphine Sulfate with Clonidine Hydrochloride Packaged in Plastic Syringes Author(s): Xu Quanyun A, Trissel Lawrence A, Pham Lien
Jan/Feb 2002 Pg. 70-73	Physical and Chemical Stability of Low and High Concentrations of Morphine Sulfate with Bupivacaine Hydrochloride Packaged in Plastic Syringes Author(s): Trissel Lawrence A, Xu Quanyun A, Pham Lien
Sep/Oct 2013 Pg. 436-438	Compatibility of Amiodarone Hydrochloride with Vasopressin During Simulated Y-site Administration Author(s): Ramaley Corrine C, Li Feng, Du Chengan
Jan/Feb 2018 Pg. 86-94	Compatibility and Stability of VARUBI (Rolapitant) Injectable Emulsion Admixed with Intravenous Granisetron Hydrochloride Author(s): Wu George, Powers Dan, Yeung Stanley, Chen Frank, Neelon Kelly
Jul/Aug 1998 Pg. 318-321	Compatibility and Stability of Ranitidine Hydrochloride with Six Cephalosporins During Simulated Y-Site Administration Author(s): Inagaki Kazuhiro, Kambara Motoya, Mizuno Munemichi, Gill Mark A, Nishida Mikio